Accurate Bioanalytical Peptide Quantification of Salmon Calcitonin Using High Resolution Mass Spectrometry (HRMS)

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Mary Lame and Nikunj Tanna
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Application Notes
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Technical Notes
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This technical brief demonstrates the ability to perform highly sensitive HRMS quantitative analysis of the peptide, salmon calcitonin, extracted from human serum using the Xevo G2-XS QTof MS, achieving an LLOQ of 50 pg/mL. In addition, this performance was comparable to the Xevo TQ-XS Tandem Quadrupole MS results, achieving LLOQs within 2-fold. This highly reproducible data (CVs <10%) demonstrates that the HRMS Xevo G2-XS QTof can be used to provide sensitive, robust, and accurate quantification of peptides from biological matrices.

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