Accurate Bioanalytical Peptide Quantification of Salmon Calcitonin Using High Resolution Mass Spectrometry (HRMS)

Library Number:
APNT134999871
Part Number:
720006382EN
Author(s):
Mary Lame and Nikunj Tanna
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Technical Notes
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This technical brief demonstrates the ability to perform highly sensitive HRMS quantitative analysis of the peptide, salmon calcitonin, extracted from human serum using the Xevo G2-XS QTof MS, achieving an LLOQ of 50 pg/mL. In addition, this performance was comparable to the Xevo TQ-XS Tandem Quadrupole MS results, achieving LLOQs within 2-fold. This highly reproducible data (CVs <10%) demonstrates that the HRMS Xevo G2-XS QTof can be used to provide sensitive, robust, and accurate quantification of peptides from biological matrices.


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