Increasing Throughput for the Analysis of Human Insulin and Related Biotherapeutic Analogs using the ionKey/MS System

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Michael Donegan, James Murphy, and Erin Chambers
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Application Notes
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Technical Notes
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Protein Quantification

This study highlights the novel and highly efficient ionKey/MS System, combined with the robust and high throughput 300 μm I.D. iKey HT separation device for the highly sensitive and accurate quantification of therapeutic insulin and five analogs using tandem quadrupole LC-MS.

The fully integrated ionKey/MS System enables bioanalysts the flexibility to modulate a microflow LC-MS system between ultra sensitivity analysis and higher throughput by simply switching between the novel iKey columns.

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