Dilute and Shoot Method for the Determination of Tobacco-Specific Nitrosamines (TSNAs) in Smokeless Tobacco Products by UPLC-MS/MS

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Naren Meruva, Dimple Shah, Xiaojie Tan, and Jennifer Burgess
Waters Corporation
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Application Notes
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Application Notes
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In this application note, we describe a UPLC-MS/MS method for TSNA analysis in tobacco products that has been developed based on the CORESTA standard (CRM-72), and provides further improvements in sensitivity, linear dynamic range, sample workflow, and overall analysis throughput.

This method is applicable to the determination of TSNAs in tobacco and smokeless tobacco products including snus, moist snuff, dry snuff, and chewing tobacco.

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