Transfer of an Isocratic USP Assay from an Agilent 1100 Series LC System to a ACQUITY UPLC H-Class System: Analysis of Tioconazole and Related Impurities

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Paula Hong and Patricia R. McConville
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Application Notes
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Technical Notes
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In this technology brief an HPLC USP method transfer from an Agilent 1100 Series LC System to an ACQUITY UPLC® H-Class System was demostrated meeting all USP method criteria.

The USP assay for tioconazole, an isocratic separation, was successfully transferred across the systems from different manufacturers. Both systems met all acceptance and system suitability requirements for the USP monograph assay and organic impurities tests and demonstrated comparable separations. These results illustrate the ability to successfully transfer USP methods from HPLC instrumentation to properly configured ACQUITY UPLC H-Class System.

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