Chiral and Achiral Profiling of a Pesticide Formulation Using the ACQUITY UPC2 System and the ACQUITY QDa Detector

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Marian Twohig, Michael O’Leary, John P. McCauley, and Rui Chen
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Application Notes
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Application Notes
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Research associated with the development of new agricultural pesticide formulations centers around the design of products that provide highly effective and specific action towards the target organism with reduced application rates.

It is estimated that 30% of the pesticides on the market today have optical isomers. However, the desired activities often result from one single enantiomer in the optical isomer mixtures. It is therefore important to assess the enantiomeric purity of the chiral active ingredients in the formulation. In addition, the detection, characterization, and quantitation of the other components in the formulation are necessary to support product registration.

The study of enantioselective properties has previously been a challenge due to the difficulty in resolving chiral compounds. The benefit of having faster analytical methods to resolve chiral compounds is that critical information pertaining to their stereoselective behavior can be obtained more rapidly leading to increased laboratory productivity.

In this application note, we describe the analytical profiling of a triazole containing pesticide formulation using UPC2 and a combination of UV and mass detection.

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