Enabling MS Technologies for Rapid Protein Structure Evaluation

Library Number:
WEBC134761583
Author(s):
Dr. Justin Benesch, University of Oxford, UK and Dr. Kasper D. Rand, University of Copenhagen, Denmark
Source:
Waters and Biocompare
Content Type:
On Demand Webinar
Related Products:
Protein Quantification
 
 
 

In this on-demand webinar Dr. Justin Benesch, University of Oxford, UK discusses “Ion-mobility mass spectrometry to separate, quantify & determine the structure of dynamic protein assemblies,” and Dr. Kasper D. Rand, University of Copenhagen, Denmark discusses “H/D exchange and mass spectrometry to characterize the conformation and interactions of complex proteins of therapeutic interest.”

Key Learning Objectives

  • The coupling of ion mobility (IM) spectrometry with mass spectrometry (MS) enables the two-dimensional separation of gas-phase ions according to ‘size’ and mass-to-charge ratio
  • To interrogate heterogeneous protein assemblies in the 10 kDa to 1 MDa range, intact in the gas phase
  • How expanding the applicability and resolution of HDX-MS technology you can seek to address current and future analytical challenges

This is the 1st presentation in the “Discovery & Life Science Webinar Series 2013.”

Panelists Biography:

Justin Benesch, Ph.D., Royal Society University Research Fellow, Tutorial Fellow in Chemistry, University College, Oxford, United Kingdom

Justin studied Chemistry at the University of Oxford, as a member of Hertford College. In 2001 he started a PhD in the laboratory of Carol Robinson in the Department of Chemistry at the University of Cambridge. During his graduate studies he was a member of Gonville & Caius College. After his PhD he spent a year as an MRC Discipline Hopping Fellow, during which he learnt electron microscopy techniques in Helen Saibil’s lab in Birkbeck College, London. Justin is now a Royal Society University Research Fellow, and a Tutorial Fellow in Chemistry at University College, Oxford.

Kasper D. Rand, Associate Professor, Ph.D., Head of Laboratory, Biomacromolecular Analysis Lab, Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark

Kasper studied Biochemistry at the University of Copenhagen (2004) and obtained his Ph.D. degree from the University of Southern Denmark (2007). He worked in the pharmaceutical industry during his graduate studies (2004-2007) and went on to do postdoctoral research in the group of Prof. Thomas. J.D. Jørgensen at the University of Southern Denmark (2007-2008). In 2008, he joined the group of Prof. John R. Engen at Northeastern University in Boston as a visiting fellow of the Danish Research Council. In 2010, he joined the group of Prof. Olivier Michielin at the University of Lausanne as an HFSP fellow. In 2011, he was appointed a faculty position as an Associate Professor at the Department of Pharmacy of the University of Copenhagen where he heads the Biomacromolecular Analysis Lab.