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DESI-Mass Spectrometry Imaging Investigation of Discrete and Cassette Drug Dosed Tissues

Library Number:
APNT134934269
Part Number:
720005947EN
Author(s):
Philippa J Hart, Andreas Danhorn, Mark Towers, and Emmanuelle Claude
Source:
Waters, and Imperial College
Content Type:
Application Notes
Content Subtype:
Technical Notes
Related Products:
Biomedical Research
 
Mass Spectrometry Imaging
 
DESI XS
 
Full Spectrum Molecular Imaging
Abstract / Summary

In this technology brief desorption electrospray ionization (DESI) mass spectrometry imaging (MSI) was used to analyse tissue sections from cassette dosed drug metabolism and pharmacokinetic (DMPK) models. The ability to map the distribution of drugs and their metabolites in the liver, alongside endogenous lipid species is demonstrated.


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