DESI-Mass Spectrometry Imaging Investigation of Discrete and Cassette Drug Dosed Tissues

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Philippa J Hart, Andreas Danhorn, Mark Towers, and Emmanuelle Claude
Waters, and Imperial College
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Application Notes
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Technical Notes
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In this technology brief desorption electrospray ionization (DESI) mass spectrometry imaging (MSI) was used to analyse tissue sections from cassette dosed drug metabolism and pharmacokinetic (DMPK) models. The ability to map the distribution of drugs and their metabolites in the liver, alongside endogenous lipid species is demonstrated.

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