How hydrogen exchange mass spectrometry can help investigate protein higher order structure

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Professor John Engen
Northeastern University
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Waters proudly sponsored the 4th International Symposium on Higher Order Structure of Protein Therapeutics at the HOS Welcome Reception on April 13, 2015. The reception took place at The Engen Laboratory, A Waters Center of Innovation, at Northeastern University. This exclusive event featured a key note presentation by Professor John Engen, a leading expert on hydrogen-deuterium exchange mass spectrometry (HDX MS).

The laboratory of John Engen performs research at the interface of Analytical Chemistry, Biochemistry, and Structural Biology. The team uses hydrogen exchange and mass spectrometry (HX MS) as its core technology to probe protein conformation, conformational changes, dynamics, protein folding, and the effects of binding.