Upstream Bioprocess Development

Take Control: Make Decisions Faster With Your Own Quality Data

Upstream Bioprocess Development engineers require a more effective and data driven optimization of cell lines and manufacturing process, aiming at maximizing drug product quality and yield. Informed decision making is often hindered due to lags up to 6 weeks to access Product Quality Attributes (PQAs) or culture media information. The number of samples that can be analyzed is consequently limited. We believe these results should be readily accessible from the hands of process engineers. Waters has joined forces with Sartorius, to uniquely deliver direct measurement of PQAs and cell culture media characteristics during clone selection and bioprocess development.

The Sartorius Ambr® 15 multiple parallel reactors systems can now benefit from dedicated workflows and connectivity to the Waters BioAccord LC-MS System. This results in maximized drug substance quality and yields, minimized downstream impurities, and accelerated development – saving time and multiple, costly optimization cycles.

• Correlate Process Input and Product Quality Outputs: Monitor cell culture media characteristics and product attributes on a single platform
• Continuous Product Quality Feedback: Access leading indicators to make decisions in near-real time
• Rely on the BioAccord LC-MS System: A high throughput, easy to deploy and to operate platform for non-expert users with seamless workflows for bioprocess assays

Bioprocess Development Brochure

Upstream Bioprocess Development engineers require a more effective and data driven optimization of cell lines and manufacturing process.

Get access to direct measurement of Product Quality Attributes and Culture Media characteristics during clone selection and bioprocess development to allow access to analytical information at point of decision.