The ionKey/MS System redefines ultimate performance by integrating microflow UPLC directly into the source of the mass spectrometer. This provides an increased level of sensitivity, chromatographic performance, and ease-of-use that cannot be achieved any other way.
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Sensitivity, throughput, and robustness with ionKey/MSThe iKey Separation Device is the ideal format for sensitivity, throughput, and robustness for microflow LC-MS analyses.
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150 µm I.D. iKey highest sensitivityThe 150 µm I.D. iKey Separation Device provides significant increases in S:N compared to 2.1 mm I.D. chromatography allowing scientists to reach lower limits of detection and see things they could not see before. ionKey/MS and 2.1 mm I.D. peaks are time aligned for comparison purposes.
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300 µm I.D. iKey HT highest throughputThe 300 µm I.D. iKey HT Separation Device is a high throughput microflow separation device enabling short cycle times and improved sensitivity over conventional UPLC methods on a timescale that is practical for routine analysis. Increasing flow rates with the iKey HT Separation Devices demonstrates the expected changes in retention time, as well as enhanced sensitivity. For high throughput applications, iKey HT Separation Devices facilitate comparable analysis times and enhanced sensitivity compared with 2.1 mm UPLC experiments. |
Simplified microflow LC-MSThese systems are enabled by the iKey Separation Device, which replaces the need for traditional fittings and error prone fluid connections. It greatly simplifies micro flow LC-MS and makes this technology easily accessable to the analytical laboratory. The “plug and play” design of the iKey Separation Device eliminates operator variability common in traditional microflow LC-MS analyses regardless of skill level. |
The iKey Separation Device is a high-pressure microfluidic device that provides sub-2-µm UPLC separations with the ionKey/MS System, enabling highly sensitive and efficient microflow LC-MS separations. The 150 µm I.D. iKey Separation Device provides the highest level of sensitivity whereas the 300 µm I.D. iKey HT Separation Device allows for short cycle times and higher throughput analysis, still at increased sensitivity level. |
The iKey with PCA Technology has an additional post column addition (PCA) channel. This allows for mixing the mobile phase with a desired solvent post chromatographic separations. Post-column addition of solvents can be used to enhance the electrospray process and increase sensitivity without affecting the chromatographic separation. |
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Robust, reproducible, and reliableEach iKey Separation Device is LC-MS tested to ensure performance not only within an iKey but from one iKey to another. The iKey also offers robust performance as it achieves high quality results, even after hundreds of injections. |
Designed for the most demanding quantitative applications, Waters mass spectrometers provide unprecedented levels of sensitivity and the ultimate in quantitative performance. This technology is available for: