Performance Solutions: UPLC/UHPLC for LC-MS

The very best in chromatography

How can I see an improvement in sensitivity from my LC-MS system?

What is the best way to develop a quantitative protein method that allows for seamless transferability?

How can I get more reliability when characterizing my complex compounds?

Our ultra-high performance LC (UHPLC) technologies with optimized configurations power up the sensitivity, repeatability, and robustness of your MS analyses and improve the quality of your data. Instantly enhance the performance of virtually any LC-MS experiment regardless of the type or brand of MS you use.

  • Support improvements in your separation resolution and reproducibility
  • Pair with UHPLC columns and get the sensitivity you need for demanding applications
  • Gain enhanced selectivity regardless of your molecule type or matrix complexity
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ACQUITY Premier System 

ACQUITY Premier System: Separation Science Redefined. Again.

The ACQUITY Premier system minimizes metal-sensitive analyte loss, improving recovery, and limits of detection. Pairing with any Waters Mass Spectrometer, the ACQUITY Premier system enables you to confidently identify and quantify unknown compounds in complex samples and confirm trace components at the lowest possible levels.


ACQUITY UPLC H-Class PLUS Quaternary System: Performance that Advances Your Lab

Simplify and streamline your method development workflow. The ACQUITY H-Class PLUS Quaternary system automatically screens multiple column and eluent combinations to identify the separation conditions that provided the best chromatographic resolution. The system provides on-demand solvent blending and support for any analytical LC column, making it an ideal choice for modernizing existing or developing new methods.


ACQUITY UPLC H-Class PLUS Binary System: Higher Throughput for Everyday Analyses

A highly reliable and robust LC-MS system without any compromise in speed, resolution, or sensitivity, especially in everyday settings. The ACQUITY H-Class PLUS Binary system combines an optimized flow path resistant to clogging, stable high-pressure gradient formation, and support for sub-2-µm to 5-µm particle columns to deliver the ideal choice for reproducible everyday LC-MS analyses with any tandem quad or Q-ToF.


ACQUITY UPLC I-Class PLUS: Complex Challenges, Solved

Your ideal chromatographic separation for yielding the tallest, sharpest peaks. The ACQUITY UPLC I-Class PLUS System arms you with the industry’s greatest resolving power and lowest system volume. Pairing perfectly with sub-2-μm particle columns, top-tier tandem quads, and HRMS instruments, the system enables the highest sensitivity analyses in research and everyday applications.

ACQUITY M-Class System

ACQUITY UPLC M-Class System: Your Inlet to MS

The most robust, reliable, and highest performing UPLC system for nano-to-microscale separations. With unprecedented usability, the ACQUITY UPLC M-Class System provides high sensitivity over a range of column dimensions and an array of applications. Succeed in analyzing compounds that are severely limited in amount or availability, even within a complex matrix.


From your date of purchase and throughout the lifecycle of your UHPLC instrument, your Waters team helps improve the performance of your laboratory, lower your total cost of ownership, and meet your evolving testing requirements.

Learn more about the Waters FlexUP Technology Renewal Program.

LC Portfolio Brochure Chromatography and LC-MS Solutions Brochure

Waters has the LC and LC-MS solutions to answer your lab's most important questions. Find the right solution to meet your specific needs.
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