Semi Preparative to Preparative-Scale SFC Purification

Purification scientists around the globe are excited by the latest advancements in supercritical fluid chromatography, or SFC, that are now backed by the powerful support of Waters. Because SFC technology uses CO2 as its main solvent, it is a critically important solution for prep laboratories that want to be more green: Less solvent to buy; less to dispose of. And SFC means much less time and money spent on both.

  • Where eco-friendly is an important consideration to high-throughput purification capabilities
  • Fully automated UV - or mass-directed purification
  • Reduced fraction drydown time increases throughput
  • Intelligent instrument control meets demanding fraction collection workflow needs with MassLynx Software's FractionLynx Application Manager


Prep 100q SFC System Waters Prep 100q SFC System is the only preparative scale, open-bed supercritical fluid chromatography (SFC) system specifically designed for seamless, mass-triggered purification.
Investigator SFC System The Investigator SFC System offers both analytical method development and semi-preparative purification. Once the optimal mobile phase and stationary phase are determined from screening, the method can be easily scaled for purification on the same system.
Optical Detectors for Purification and Modular LC Systems HPLC optical detectors provide additional analytical detail about your samples. When paired with their accessories, such as flow cells or nebulizers, you can obtain more information per run, fulfilling multiple detection strategy requirements.