ScanWave

ScanWave - Better spectral data from tandem quadrupole MS

Conventional tandem quadrupole MS instruments are sensitive enough when used to monitor targeted compounds in MRM mode, but they are significantly less sensitive when used to acquire data in spectral mode.

ScanWave technology allows ions within the collision cell to be accumulated and separated according to their mass-to-charge ratio (m/z). Synchronizing these ions with the scanning of the second quadrupole significantly enhances product ion spectra, enabling you to more easily confirm the identities and structures of your analytes of interest.

Product ion confirmation scan (PICS)

ScanWave-enhanced product ion scans are triggered from the detection of a target analyte in MRM mode. This enhanced spectrum may be used as confirmatory data to add evidence that the MRM trace is the true target compound. The PICS spectrum can be library matched against a reference from database, enabling a routine method of checking.

The speed of PICS mode means that it is UPLC compatible, maintains the integrity of the MRM chromatographic trace for quantitative measurements, and can be employed even at the LLOQ.

RADAR

RADAR is a simple acquisition mode that acquires both MRM and full scan MS simultaneously, a unique capability that can both simplfy and accelerate development of robust methods.

• Track interferences during method development, to optimise chromatography
• Capture positive and negative ion data to monitor matrix interferences during a routine quantitative analysis
• Capture a full picture of the sample, not just the target analyte, by enabling detection of impurities, degradants or metabolites

RADAR is a standard feature of all Xevo tandem quadrupole MS systems.