Accelerate your research and comprehensively identify analytes in your complex samples with the SELECT SERIES MRT, built with state-of-the-art Multi Reflecting Time-of-Flight (MRT) technology.
High resolution mass spectrometry, without compromise
The SELECT SERIES MRT provides a unique combination of ultra-high resolution and specificity, independent of scan speed, resulting in unambiguous compound identification with even the most complex samples.
Distinguish the fine isotope structure of small molecules, resolve nominally isobaric interferences, and baseline resolve the isotopic envelope of multiply-charged ions with high resolution MRT technology. Unlike other high-resolution mass analyzers, with MRT there is no compromise to your experiments; mass resolution is consistent over a broad mass range and scan speeds.
The SELECT SERIES MRT achieves groundbreaking Time-of-Flight (ToF) resolution with the innovative use of multiple reflections of the ion beam between two gridless electrostatic mirrors in the mass analyzer. This extends the ions’ flight path, spatially refocusing the ion packets through a series of periodic lenses after each reflection maintaining sensitivity.
The superior performance of the SELECT SERIES MRT results in high precision and routine part-per-billion mass accuracy independent of acquisition speed, providing unsurpassed quality of mass spectrometry data and information. The instrument is operated via the SELECT SERIES MassLynx acquisition system with simple and intuitive experimental setup, acquisition, and processing of mass spectrometry data for imaging experiments. Data is recorded in the widely deployed Waters .raw file format, which can easily be accessed via the MassLynx API, exported as (i)mzML, and other interchangeable data formats, ready to use in your data analysis strategy.
The SELECT SERIES MRT reduces analysis times by providing crystal clear, high-resolution images, acquired at fast imaging speeds without compromising mass spectral resolution or accuracy.
This enables accelerated mass spectrometry imaging experiments while still resolving analytes from interferences, revealing fine structural information. The cutting-edge technology and intuitive software combine to revolutionize mass spectrometry imaging for a wide range of applications; where the ability to map compounds that differ by only a few mDa is changing the pace of research. This includes:
Maximize your mass spectrometry imaging capabilities and analytical flexibility with both DESI and MALDI on the SELECT SERIES MRT. This quadrupole time-of-flight mass spectrometer can be paired with either the DESI XS source or the high-performance SELECT SERIES MALDI source, so you can utilize Full Spectrum Molecular Imaging (FSMI) in your experiments.
The complementary nature of these techniques enables different molecules to be ionized on the same tissue surface, pinpointing the spatial localization of a wide range of biomolecules and pharmaceutical compounds as they are desorbed from tissue sections. This provides superior accuracy for compound identification.
Confident biolocalization and identification
The accompanying video shows the differential spatial distributions of seven distinct, clearly resolved ions, all contained within a <150mDa window, that are easily visualized from a mouse brain tissue section. Moreover, the accurate mass data can be database searched to provide accurate identifications.
DESI XS and the SELECT SERIES MRT
DESI XS produces high quality data allowing for clear visualization of molecular spatial distributions. The speed and versatility of DESI imaging makes it best suited to the analysis of lipids and other small molecules under ambient, direct analysis conditions, without the need for additional matrices.
The improved sensitivity, usability and robustness of DESI XS opens the possibility of mass spectrometry imaging to even more research laboratories, while the performance of the SELECT SERIES MRT ensures you can tackle the most challenging analytical problems with ease.
Redefining MALDI imaging
The new high-performance MALDI source for the SELECT SERIES MRT improves both imaging performance and ease-of-use, enabling large tissue sections to be rapidly imaged at high spatial resolution, with improved selectivity and sensitivity. The novel source design uses a tightly focussed laser beam profile, increasing signal-to-noise at high spatial resolutions and providing lateral resolution of 15µm without oversampling, in addition to data acquisition rates >10 pixels per second. These features enable high intensity images to be acquired quickly and efficiently.
Come and say hello at Waters Booth #219 for ASMS 2021, live in Philadelphia from October 31 – November 4. We look forward to seeing you there!
Find Out More
With this latest advancement in high resolution MS, we are excited to see a new era of discovery unfold.
Find out about the latest developments in mass spectrometry on Wednesday, October 27