Progenesis® QI enables you to accurately quantify and identify compounds in your samples that are significantly changing. With support for all common vendor data formats and a highly-intuitive menu-guided workflow, Progenesis QI software helps to overcome your data analysis challenges, enabling you to rapidly, objectively and reliably discover compounds of interest. |
Unlock complex data with powerful visualizationOne of the key features of Progenesis QI is its highly graphical and attractive data displays which allow you to fully visualize and understand your data, giving added confidence in the measurements made. Ion-intensity maps showing the 2D-representation of chromatographic retention time, m/z and feature intensity, as well as MS and chromatographic data views, provide quality assurance of automatic alignment, peak picking and compound adduct deconvolution for every sample. |
Highly accurate quantification of compoundsProgenesis QI provides both accurate and precise measurements of compounds based on their summed ion intensities. All compound adducts are automatically deconvoluted to provide accurate quantification from all available data. Following quantification, it is possible to identify compounds having statistically significant abundance changes across groups. Large numbers of samples from multiple groups can be explored, along with multiple comparison designs within a single experiment. The result is a list of compounds of interest for further characterization. |
Confident compound identification with multiple search parametersProgenesis QI allows you to search for compound identifications based not only on neutral mass, isotopic distribution and chromatographic retention time, but also using MS/MS fragment data and collision cross section (CCS) measurements. This is made possible using our novel Metascope search engine. Database searching using multiple parameters greatly improves the specificity of the search and increases the chance of correct compound identification. |
Compound ID is still one of the main bottlenecks in small molecule ‘omics experiments so we provide access to a wide variety of databases to increase your chance of finding your compounds of interest.
Guided data processing workflowThe menu-guided workflow in Progenesis QI helps guide you through the experimental steps in the software. If required, automation routines allow you to seamlessly move through multiple stages to maximize opportunities for unsupervised overnight and weekend data processing (v2.0 feature).
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Statistical analysisFind compounds of interest using statistical tools included in Progenesis QI, including:
Or additionally, take advantage of advanced statistics via seamless integration with EZInfo 3.0 (Umetrics, v2.0 feature) giving access to functions such as supervised analysis and s-plots. |
One of the major bottlenecks in ‘omics experiments is often the interpretation of the list of discoveries – what is the biology behind the changes observed? One way to address this question and extract maximum value from ‘omics discovery data is Pathway Analysis. Progenesis QI provides export tools to quickly and easily interface with third-party Pathway Analysis programs.
Progenesis QI is instrument platform independent supporting LC-MS data from Waters, Thermo, ABSciex, Agilent, and Bruker. Also supported are universal formats such as .mzML, .mzXML and NetCDF.
For more information about Progenesis QI, please see www.nonlinear.com.