Modular Systems

Modular Systems

Flexible purification solutions to meet your lab requirements

Flexible purification solutions to meet your lab requirements

Integrate the versatility of Empower Software with the simplicity of Waters chromatography solutions for a flexible purification solution that perfectly meets your laboratory’s needs.

With Waters analytical to semi-preparative purification solutions, you can effectively purify a limited number of samples without the advanced features of a full preparative system. Waters modular systems can sit on the end of the benchtop waiting for your chemists to use on-demand and are ideal for purifying micrograms to milligrams of your compounds.

Configure the ideal system solution to meet your unique applications with Waters full line of modular solvent delivery systems, capable of delivering flow rates of up to 300 mL per minute.

LC Prep 150 System Modular Systems

Overview

  • Easily manage ever-increasing workload demands— from a few samples a day to a few hundred— with robust and reliable systems that offer confident, unattended operation
  • Scale-up from analytical to preparative chromatography seamlessly with flexible configurations
  • Stay just a few clicks away from purification results with Empower Software for acquisition, real-time monitoring, and total results management
  • Configure your system according to your throughput and scale requirements for manual or automated injections
  • Accommodate flow rates up to 300 mL/min with flexible solvent delivery capabilities
  • Manage your solvents and samples with a user-friendly console and time-saving software features for manual or automated injections
  • Obtain the highest sample loading and unmatched column stability with Waters proprietary Optimum Bed Density (OBD) Column

Recommended Use: For achieving optimal purification of compounds of interest, from micrograms to milligrams.

Typical Column I.D.

Typical Column I.D.

Maximum Flow Rate 

Maximum Flow Rate 

Solvent Management

Solvent Management

Sample Load

Sample Load

2.0 to 19.0 mm

22.5 mL/min

1525 EF

µg to 10s of mg

4.6 to 30.0 mm

50.0 mL/min

2535 Quaternary Gradient Module

mg to g

4.6 to 50.0 mm

150.0 mL/min

2545 Quaternary Gradient Module

mg to g

7.8 to 75.0 mm

300.0 mL/min

2555 Quaternary Gradient Module

mg to 10s of g

Maintain control and get answers fast with the integrated functionality of Empower

Control the Waters Fraction Collector III through an instrument interface using Empower Software. The interface integrates seamlessly with existing Empower control components once the instrument control software (ICS) is loaded. The collector control software lets you easily configure collection vessels and program your collection routines. Receive real-time feedback from the fraction collector and obtain information on the current state of the collection process along with the location of the collected fractions for immediate answers.

Perform a variety of collection techniques with efficiency and ease

With the user-friendly collection control interface, you can easily perform a variety of collection techniques:

  • Collect everything with time slicing
  • Collect specific segments of the run on a time basis
  • Collect the eluent between triggered fractions
  • Collect using detector-triggers based on threshold, slope, or slope and threshold

When large-volume samples require repetitive injections and collecting fractions into the same container, simply check a single box in the collection protocol to perform this task. For low-flow operations, you can choose to avoid opening and closing the diverter valve between consecutive fractions, eliminating the risk of diverting valuable segments of the sample to waste.

Fraction collection information is embedded into Empower Software datasets and is available in a comprehensive report. You can view the report in an electronic format and save it to the database for follow up retrieval as needed.

Integrate fraction collection and detection for reliable results

Perform fraction collection efficiently with Waters compact, flexible, and easy-to-use Fraction Collector III, which you can use alone or as part of a Waters sample purification solution for greater sample collection capacity. It is designed for use in both small-scale and large-scale work environments and can easily integrate with many Waters system configurations.

Streamline your analytical and semi-preparative purification workflows by integrating a Waters detector to meet your separation scale requirements. Our detection technologies are synonymous with sensitivity, stability, and usability, delivering what you need to tackle your laboratory’s challenges. Choose the right detection option for your applications from:

  • Ultraviolet/Visible (UV/Vis) Absorbance
  • Evaporative Light Scattering (ELS)
  • Photodiode Array (PDA)
  • Evaporative Light Scattering (ELS)Mass Spectrometry (MS)
  • Analog

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Documents

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Related

Waters Fraction Collector III
Precisely perform fraction collection in chromatography with the easy-to-use Waters Fraction Collector III. Use it alone or as part of a Waters sample purification system for even greater sample collection capacity.

Purification Solvent Management
Waters HPLC solvent pumps enable you to customize HPLC platforms to accommodate for solvent delivery systems, for isocratic or gradient, analytical or preparative purposes.

Chromatography Detectors
Waters UPLC/UHPLC, HPLC, and SFC optical detectors provide additional analytical detail about your samples so you can obtain more information per run.

Empower Software Solutions
Analyze samples without downtime with Empower Software Solutions, which combines Waters industry-leading Empower Chromatography Data System (CDS) and Empower Lab Management System (LMS).
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Modular Systems FAQs

How flexible are the modular systems in terms of flow rate and column size?
Waters modular purification systems offer a wide range of flow rates and column dimensions, allowing users to tailor the setup to their specific purification needs. Flow rate capabilities range from 22.5 mL/min to 300 mL/min, supported by a selection of solvent delivery modules, including the 1525 EF, 2535, 2545, and 2555 Quaternary Gradient Modules. Column compatibility spans from 2.0 mm to 75.0 mm internal diameter, covering purification from microgram to tens-of-gram scales.

Can I scale up from analytical to preparative workflows using the same system?
Yes, Waters modular systems are designed for seamless scale-up from analytical to preparative workflows. The same system platform supports a wide range of column sizes and flow rates, enabling users to move from microgram-level screening to milligram- or gram-scale purification without needing to change core components. Solvent delivery modules and injection options are configurable to match the evolving scale of your purification tasks. Empower Software ensures continuity in method control and data handling across all scales, simplifying workflow transitions.

What fraction collection options are available, and how are they controlled?
Waters modular systems use the Fraction Collector III, a compact and versatile tool designed for both small- and large-scale purification workflows. It supports a wide range of collection techniques, including time slicing, detector-triggered collection based on signal threshold or slope, and consecutive fraction pooling. The collector is fully integrated with Empower Software, which provides a user-friendly interface for configuring collection parameters, viewing real-time collection status, and embedding fraction data directly into the acquisition dataset.