MassLynx MS Software

Acquire, Analyze, Manage, and Share Mass Spectrometry Information

MassLynx™ Software increases the speed at which you can convert your sample data into valuable knowledge. It provides you with the fundamental platform to acquire, analyze, manage, and share your mass spectrometry information.

MassLynx intelligently controls any Waters mass spectrometry system, from sample and solvent management components to mass spectrometer and auxiliary detectors. MassLynx Software may acquire nominal mass, exact mass, MS/MS and exact mass MS/MS data.

MassLynx’s Sample List is the core of the system. It maintains and consolidates the data on all of your samples. You also initiate any activities related to your sample from the Sample List. This "sample centric" approach simplifies the interaction with your LC/MS or GC/MS system, acquired data and processed results.

Process Application-specific Data

MassLynx Software features general purpose and specialized Application Managers that provide information for your specific MS analyses and data. One comes as standard with MassLynx:

• OpenLynx™ for qualitative screening and identification

Optional Application Managers can perform:

• Targeted quantitative analysis
• Mass-directed purification
• Metabolite identification
• Deconvolution of complex chromatograms
• Metabonomics & metabolomics
• Protein identification and protein characterization

Intuitive Operation

MassLynx requires a minimal learning curve ― even novice users can operate the instrument and become productive in no time. The MassLynx toolbar provides instant access to instrument status information, sample queue and Application Managers. A single mouse click switches between views of the queue and instrument status while tabs select general or application-specific tools.

MassLynx toolbar and Sample List

Intelligent Instrument Control

MassLynx Software harnesses the real-time intelligence built into every mass spectrometer.

With IntelliStart™ technology integrating the internal calibration fluidics and diagnostics software, the software automatically tunes and calibrates your UPLC/MS and UPLC/MS/MS and conducts full UPLC/MS/MS performance checks. This allows your chromatographers to easily acquire UPLC/MS/MS data in routine analytical and open access applications.

MS^E employs a data-independent methodology to provide molecular and structural information for every detectable component from a single experiment. Meanwhile, Data Directed Analysis (DDA™) allows automatic switching from MS to MS/MS acquisition when a compound of interest is detected.

MassLynx fully supports various ionization sources, including:

• ESI
• APcI
• ESCi^®
• Multi-Mode Ionization
• IonSABRE™
• APcI
• Photoionization (PI)
• LockSpray
• NanoLockSpray™
• MUX-technology™
• GC
• Direct probes
• MALDI MS

Automated Data Processing

MassLynx™ Application Managers streamline application-specific data processing. MassLynx includes two Application Managers:

OpenLynx for Qualitative Analysis

OpenLynx™ Application Manager performs peak detection on your LC/UV, LC/MS, LC/MS/MS or GC/MS data and then carries out specified higher-order processing. Processing may be as simple as a subtracting a background spectrum or as sophisticated as predicting the elemental composition of analytes based on exact mass and isotope patterns.

Typical uses include:

• Confirmation of synthetic products
• Estimation of purity and yield of synthetic reactions
• Elemental composition predictions
• Compound identification using user-created or commercial spectral libraries

Integrate with Informatics

MassLynx Software offers automated integration with Laboratory Informatics solutions, including Waters NuGenesis^® SDMS.

Software features a 21 CFR Part 11-compatible security system built on the latest file encryption, audit log, and secure archival/retrieval technology. The flexible security system allows you to tailor and deploy security policies that meet the requirements of your laboratory.

Working in a Regulated Environment

Key components of MassLynx software security system include:

• Security Manager — Configure access privileges for each user, and deploy operator, administrator, and maintenance policies to meet your security protocols. Multiple user groups with access to other projects areas are permitted fully-secured operation when required and operation in more open projects with more open privileges when appropriate
• Secure File Encryption — The latest encryption and checksum technologies prevent accidental or deliberate tampering with files. Add electronic signatures with an optional component of the secure file system
• Audit Log — An un-editable, hidden, encrypted file automatically records all logon and logoff events and security policy changes. MassLynx program module monitors all file generation or manipulation activities or events. This log file can be viewed and searched using LogLynx™. In addition to the MassLynx security system audit log, the QuanLynx Application Manager has a detailed audit log that records the specifics of quantitative data processing
• Secure archival and retrieval — Archive and restore secure data without compromising date and file integrity