Bringing together the powerful technologies of MALDI and DESI to discover, identify and measure a broad range of molecular targets in a single system solution with dedicated acquisition, processing, and visualization software.
Combination of advanced Mass Spectrometry imaging technologies
A choice of complementary ionization techniques provides flexibility and delivers multi-layered, information-rich data from a single sample.
Matrix Assisted Laser Desorption Ionization (MALDI)
Desorption Electrospray Ionization (DESI)
Multiple Experiments with the Same Sample
Many applications demand the maximum amount of information from the minimum of sample.
The non-destructive nature of DESI means that a single tissue section can be analyzed multiple times, for example at different spatial resolutions or in different polarities, without significant degradation of signal or modification of chemical signature.
Following multiple DESI analyses, the same tissue section can then be used for further analysis, for example histological staining or analysis by MALDI MS imaging.
MS imaging with the power of Ion Mobility
Unlike UPLC-MS, MS imaging does not involve any form of separation prior to ionization. The resulting data are often highly complex due to the level of detail observed and the potential for background interferences.
SYNAPT HDMS enables the powerful combination of MALDI and DESI imaging with ion mobility-mass spectrometry. This allows the gas phase separation of ions by compound class and charge in an MS imaging experiment, providing a level of selectivity that would not be possible with mass resolution alone.
The result of this is cleaner imaging data, allowing the more precise visualization of molecular distributions in the presence of background.
Available on IMS MS/MS or MS/MS platforms
Waters QTof systems provide the ideal platform for MS imaging, with superior performance, proven robustness and reliability, and the flexibility to adapt to changing priorities and future needs. Highly efficient fragmentation is achieved via low energy collision induced dissociation (CID), while orthogonal geometry means that key performance attributes such as resolution and accurate mass are unaffected by changes in sample surface topography.
SYNAPT XS HDMS
For the ultimate in research grade multi-mode MALDI and DESI MS imaging
Xevo G2-XS QTof
For accessible, routine DESI MS based imaging
Steve Hattan, Principal Scientist at Waters, partnered with MIT.nano to present a seminar on engineering a mass spectrometry imaging system that challenges the current paradigm for tissue characterization.
Watch the Seminar