Mobile phase additives (ie. strong acids or buffers) are commonly used in liquid chromatography (LC) to improve analyte retentivity and peak shape. For MS applications, high purity mobile phase additives are necessary to reduce background contribution and ensure data quality. IonHance modifiers can be used for LC and LC-MS techniques, such as reversed-phase separations of proteins, peptides, and small molecules. Purified to achieve low metal content and high-quality standards, IonHance modifiers can improve sensitivity, retentivity, and peak shape of the toughest separations.