BioResolve SCX mAb Consumables

Cation-Exchange Solutions for mAb Charge Variant Analysis

An inclusive solution (columns, standards, and mobile-phase concentrates) for characterizing, monitoring, and quality control testing charge variants of mAb-based therapeutics from discovery and development through manufacturing. Scientists can easily obtain desired data using defined methods on any LC platform without sacrificing performance. The benefits include:

Ability to reliably separate, with accurate charge variant quantitation, a wide range of mAbs using optical or LC-MS compatible mobile phases
Excellent batch-to-batch and column-to-column performance consistency
LC system (HPLC, UHPLC, UPLC) agnostic, doesn't compromise required separation performance
Waters, NIST-based, mAb Charge Variant Standard is available to help confirm LC system and column performance
QR-code enabled to help obtain relevant information anytime and anywhere

Buy Now

Overview

Literature

Application Notes

Support

zoom	Flexible, Reproducible, High-Resolution Separations Charge variant analysis for monoclonal antibodies and other proteins is a critical quality attribute to understand. This product portfolio offers a solution-based platform for LC and LC-MS users utilizing robust salt and pH gradient methods.

Next Generation IEX Column Technology

The BioResolve SCX mAb Columns are based on non-porous, 3 μm particle for optimal protein diffusion kinetics and pressure tolerance for use on HPLC, UHPLC, and UPLC systems.

Non-porous polymeric particles minimize analyte band spread and enhance mAb separations
Optimal sulfonic acid ligand grafting and hydrophilic surface chemistry for superior component recovery, peak shape, and component resolution

zoom

BioResolve RP mAb Polyphenyl Columns Infographic | Waters

Increased Lifetime Without Sacrificing Performance

Guard columns are commonly used to prevent the unintended injection of sample of eluent particles that could adversely impact column lifetime. The VanGuard FIT (Fully Integrated Technology) is integrated into the column, providing ease-of-use without sacrificing performance, and ensuring maximum column lifetime.

BioResolve CX pH Buffer Concentrates

Designed alongside the BioResolve SCX mAb Columns, these buffer concentrates are:

Patent pending, pH gradient, system mobile phases for simple-to-implement charge variant profiling
Carefully optimized pH 5.0 to 10.2 gradients for use with the cation-exchange column to achieve high resolution, robust separations
100 mL 10x concentrates for the preparation of mobile phase using a simple 10-fold water dilution

BioResolve CX pH Buffer Concentrates | Waters

zoom

Protein Ion-Exchange Columns | Ion-Exchange Chromatography | Waters

IonHance CX-MS pH Buffer Concentrates

Developed for use with the BioResolve SCX mAb, 3 μm Columns, and designed to deliver robust, charge-based separations and high-quality, MS-spectral data.

Specifcally formulated for reproducibile LC-MS analyses of Intact mAb and mAb IdeS digests
Deliver cleaner spectra, significantly reduce non-desired noise, super charging, and ion suppression
Easy to use. Simply add high-quality, MS-grade water to the 10x buffer concentrates that are shipped in 1 L MS-certified LDPE bottles to minimze buffer contamination