Alliance HPLC System

Defined by dependability - today, and in the future

Time-tested, flexible, and reliable workhorse for your HPLC separations
Integrated solvent and sample management with consistent system-to-system performance and high reproducibility
A history of continued system improvements ensures the hightest in HPLC performance
Simplify your daily LC system start-up with advanced software functionality

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Excellence through the years

The consistency of the Alliance HPLC System gives you exceptional confidence in your analytical results, day-to-day and year-to-year.

Get accurate and reproducible results with Waters' flagship HPLC technology, which provides consistent and reliable performance whether your Alliance HPLC System is newly manufactured, or you're working on one that is several years old.

Comparison of the separation of carbamates using two different Alliance HPLC Systems, manufactured 7 years apart. The results are equivalent.

Performance that exceeds your method requirements

High injection precision for precise quantification, and exceptional retention time repeatability aid in accurate peak identification, the Alliance HPLC System ensures the reliability of your results.

The solvent delivery system features quaternary blending with a fixed delay volume for consistent and predictable results, regardless of system back pressure. Flexible injection capabilities cover a wide injection volume range (up to 2 mL) with excellent carryover performance, typically below 0.005%.

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USP method for Budesonide on the Alliance HPLC System.

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By adding mass detection with the ACQUITY QDa Detector to an existing Alliance HPLC System with UV detection, the peaks of interest in this Golden Seal sample can be easily identified by the m/z values.

Advancements in LC chemistry and mass detection

Improve your laboratory's efficiency using CORTECS 2.7 μm Columns with your Alliance HPLC System. Benefit from improvements in both resolution and a reduction in run times when transferring from a 5-μm chemistry.

Increase confidence in your data by adding mass confirmation with the ACQUITY QDa Detector, which is as simple to use as a photodiode array detector and can easily integrate into your existing workflow. Analysis in Empower 3 Software combines the data from the UV/Vis and MS peaks to give mass information to each peak in the separation.

Features and Benefits

Quaternary solvent blending supports isocratic and gradient applications with 11 unique gradient profile curves. Blend up to 4 solvents in any proportion with Auto-Blend Technology. Compatible with a wide range of solvent types to support reversed-phase, normal-phase, GPC, SEC, and IEX application.
Advanced solvent delivery capabilities. Serial flow path with pulse-free solvent delivery without the use of dampeners. Online solvent degassing and automated solvent compressibility for accurate flow. Integrated seal wash for robustness operation with all solvent types is standard.
Up to 120 vials housed in an optional, temperature-controlled environment. Active and user programmable needle wash for low carryover. Variable injection volumes from 0.1 to 100 uL standard, and up to 2 mL optional. Supports STAT samples and auto-addition.
Optional column heating or heating/cooling. Get the flexibility of running multiple methods on demand with optional column switching.
Detection capabilities include photodiode array, UV/Vis, fluorescence, refractive index, evaporative light scattering, electrochemical, conductivity, and mass detection.
An intuitive user interface, giving you instant access to system settings through the large LCD screen. Simplified daily set-up with SystemPREP.
Supported in Empower, MassLynx, and several 3rd party software packages
Compliance-ready. Qualification of laboratory instrumentation is an integral part of compliance with regulatory and quality standards such as GMP, GLP, ISO 17025, USP <1058>, and others. The Alliance HPLC System supports Waters Empower-based automated system qualification tool (SQT), which minimizes the time and cost associated with annual qualification.

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