ACQUITY RDa Detector
Delivering SmartMS to the masses
Increase productivity, improve data confidence and simplify routine accurate mass workflows with the new ACQUITY RDa Detector.
Compact, compliance-ready and easy-to-use, the ACQUITY RDa Detector ensures your entire laboratory can easily access high resolution mass measurements to instantly start working smarter, not harder. Compatible with a range of ACQUITY separations systems, optical detectors, and column management modules on the waters_connect software platform, your lab will get the compact LC-MS system you need for more informed decision-making in your small molecule workflows.
ACQUITY RDa Detector
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Specifications
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Ionization mode |
Electrospray Ionization (ESI) Adjustment-free high performance ZSpray™ dual-orthogonal atmospheric pressure ionization electrospray interface for robustness and reliability. Integrated adjustment-free plug-and-play probe for reduced dispersion and reliability |
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Mass analyzer |
The instrument is equipped with a high resolution, high stability Tof mass analyzer |
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Vacuum system |
A fully automated and differentially pumped vacuum system comprising of an air-cooled split-flow turbo pump and one rotary backing pump (oil free pump option available) |
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Scan speed |
1 to 20 Hz |
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Acquisition modes |
Full scan (MS) Full scan with fragmentation (data independent acquisition) |
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Mass range |
Positive ion: 50–2000 or 400–9000 m/z Negative ion: 50–2000 or 400–5000 m/z |
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Mass measurement accuracy |
RMS error <2.5 ppm measured using consecutive repeat measurements of sodium and rubidium iodide, with Lock Mass correction |
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Mass scale calibration accuracy |
<1 ppm with internal Lock Mass correction over range 50 to 2,000 m/z |
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Mass resolution |
>10,000 FWHM measured on a singly charged ion between 550 and 650 m/z. The instrument will be tuned using the automated setup and calibration routine |
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Positive ion MS sensitivity |
Intensity ≥22,000 ions/counts per second, measured from the peak at m/z 556.28 from a solution of 150 pg/µL leucine enkephalin + 500 pg/µL caffeine + 100 pg/µL pentane |
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Negative ion MS sensitivity |
Intensity ≥13,750 ions/counts per second, measured from the peak at m/z 554.26 from a solution of 150 pg/µL leucine enkephalin + 500 pg/µL caffeine + 100 pg/µL pentane |
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Chromatographic dynamic range |
The dynamic range is ≥4 orders of magnitude measuring replicate UPLC injections of lidocaine, monitoring the ion at m/z 235 |
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Regulatory approvals/marks |
CE, CB, NRTL (CAN/US), RCM |
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Software |
Systems supported in waters_connect Software version 4.0.0. |
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Health System |
The ACQUITY RDa Detector has an automated instrument set-up and calibration routine for consistent results between users of all experience levels. The ACQUITY RDa Detector monitors instrument performance from run-to-run to ensure high quality data and increased confidence in your results. If a fault occurs, the software will display information that provides step-by-step guidance to fix the fault. |
Overview
- High-quality data with the ability to identify analytes with speed using accurate, reproducible mass measurements, for confidence in results day in, day out
- Informed decision-making with intelligent diagnostics monitoring system health providing guidance as needed to resolve problems, reduce downtime and ensure consistent results that accelerate decision-making
- Easy deployment with intuitive interface and one-button start-up on a compliance-ready, compact system to reduce training time in your laboratory
- Fast turnarounds with immediate access to high resolution mass measurements, reducing the need to outsource high resolution measurements, resulting in time, cost, and productivity efficiencies
Recommended Use: For informed and smart decision making in routine analysis using small molecule workflows.
Features Header
Attain accurate mass measurement with SmartMS
Enhance your laboratory credentials, improve efficiency and increase productivity with a simple compliance-ready SmartMS solution. The ACQUITY RDa Detector, coupled with the ACQUITY UPLC I-Class PLUS with optional TUV or PDA Detectors, is built for the waters_connect platform and uses small molecule workflows for informed, smart decision making.
Pharmaceuticals – Quickly characterize unexpected chromatographic peaks, limiting disruption in development.
Food & Environmental – Establish the integrity of food efficiently with an accessible accurate mass LC-MS system.
Natural Product Screening – Evaluate outcomes without the need for a MS expert, using end-to-end robust, reliable workflows.
Academia – Publish impactful research with easy access to accurate mass measurements.
Forensics – Accelerate your laboratory’s turnaround times for seized drug sample analysis with comprehensive screening.
Forensics
Seized drug analysis
Pharmaneutical
Forced degradation and impurity analysis
Natural Products
Screening and library searching
Omics
Lipid profiling
F&E
Gross level contaminants
General
Accessible accurate mass measurements
Ideal for industry requirements
The ACQUITY RDa Detector is ideal for industry requirements like impurity analysis and degradation studies with pharmaceuticals, and assessing food integrity with Food and Environmental. With ACQUITY RDa Detector, your lab can quickly identify analytes, for more informed, data-driven decision-making in your industry workflows.
Impurity profiling of an active pharmaceutical ingredient (API) is an essential part of drug development. To ensure the safety and quality of the API, it is critical to characterize the degradation pathways and the impact of storage conditions on the drug product. The SmartMS-enabled ACQUITY RDa Detector quickly generates high quality accurate mass datasets in busy and diverse labs, providing confidence in your data.
In the Food and Environmental space, consumers are increasingly interested in how their food is grown, processed, and brought to market. This continues to put demands not only on the regulators to protect consumers, but also on food business operators to maintain their brand reputation. The ACQUITY RDa Detector offers a powerful combination of high-efficiency UPLC separations with SmartMS technology and intuitive software for data processing and review, enabling labs to screen sample extracts for possible contamination and/or fraud.
Streamline natural product screening
Natural product isolates in a research setting require a streamlined screening workflow for rapid identification, while any commercially supplied natural products claiming therapeutic properties must adhere to rigorous characterization and quality control criteria enforced by regulatory agencies.
The ACQUITY RDa Detector enables researchers and manufacturers to generate data with confidence to screen product isolates/extracts with great accuracy or adhere to the regulatory standards for purity and contamination assessment of raw materials. This delivers rapid natural product analysis with integrated library searching functionality using simple, end-to-end workflows.
Simplify walk-up accurate mass confirmation studies
Combining the ACQUITY RDa Detector with SpectralWorks’ RemoteAnalyzer offers busy analytical labs a complete walk-up accurate mass confirmation solution.
With the ACQUITY RDa Detector’s SmartMS technology and intuitive RemoteAnalyzer software, scientists in academic institutes and industries performing walk-up mass measurements can access an effective solution for small molecule accurate mass confirmation studies. The RemoteAnalyzer software operates through a web-based browser for sample submission, acquisition processing, and reporting, while the simplified user interface provides control to the administrator.
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