Xevo TQ-S

A step change in sensitivity with the Xevo TQ-S

Designed for the most demanding quantitative UPLC-MS/MS applications. The ultimate in tandem quadrupole performance allows you to achieve unrivalled sensitivity and robustness, available to everyone due to the accessibility of the Xevo platform.

Class leading sensitivity and robustness.
Qualitative information when you need it most.
Accelerated method development for sensitive and robust methods.
Reduces complexity, increases ease of use, and ensures the correct result every time.
The widest range of ionization capabilities today, future-proofing for the innovations of tomorrow.

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Overview

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First image shows increased sensitivity for Prostaglandin in negative ion electrospray using Xevo TQ-S with StepWave. Second image shows 6000 on column injections of 0.5pg/µL Verapamil in protein precipitated plasma.

Class leading sensitivity and robustness

The innovative StepWave ion guide, delivers the highest levels of sensitivity and robustness. The Xevo TQ-S enables the lowest detection limits to be achieved for the most challenging analyses, whilst maintaining instrument up time, due to the innovative active separation of ions from neutrals.

Qualitative information when you need it most

With its unique collision cell, Xevo TQ-S enables you to better address your analytical needs with the option to operate in ScanWave enhanced product ion scanning mode. This mode enables you to more easily confirm the identities and structures of your analytes of interest, at the low concentrations required. What’s more, this is done whilst retaining all of the capabilities of the standard T-Wave collision cell. This ensures the very best MRM quantification data for your demanding, high speed, and high resolution UPLC-MS/MS assays.

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ScanWave enhanced qualitative spectrum dominated by correct fragment ions, for 50fg Reserpine on column.

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RADAR data enables rapid decision making during sample clean-up method development

Understanding sample complexity

Some challenges for quantitative methods are:

Calculating compound concentrations in addition to the detection of unexpected contaminants.
Characterisation of the background matrix for every sample, increasing data quality.
Detection of analytes that are not in a targeted multiple reaction monitoring (MRM) screening method.
Improving method development by discovering more matrix components.

These challenges may be overcome by using RADAR which is the ability to obtain full scan (MS) and MRM (MS/MS) data simultaneously.

Product Ion Confirmation scanning (PICS) allows you to have full confidence in your results. Activated by a single check box in the method editor, PICS automatically triggers a product ion scan when a peak is detected by MRM.

Ensures the correct result every time

Prepare – IntelliStart™ and Quanpedia™ enable rapid, automated set-up and checking of the system and all of its methods, coupled with automatically scheduling MRM transitions to maximize performance.

Analyze – During analysis, QCMonitor will actively monitor the data in real time, taking action if any user specified tolerances are exceeded.

Interpret – TargetLynx provides automated quantification and reporting, with automated highly visible flags reducing the possibility for error.

Decide –TrendPlot enables you to visualize results over many days, weeks or months; providing valuable information on data trends and long term system performance.

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Waters universal ion source architecture, easy to use and interchangeable within minutes.

Ion source flexibility comes as standard

Universal ion source architecture ensures coverage of every application, with unlimited potential. The Xevo range of mass spectrometers all have multiple ion source options which are interchangeable in minutes and provide optimal ionization for each function required in the laboratory. The Xevo TQ-S may be used with ESI, ESCI, APCI, APGC, ASAP, nanoflow ESI and ionKey and is also compatible with DESI (Prosolia), DART (IonSense) and LDTD (Phytronix) ion sources.

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DMPK and Bioanalysis Knowledge Center

Peptide and Protein Bioanalysis Application Notebook

T-Wave technology
Precise manipulation
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Featured Xevo TQ-S Peer Review Journal

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