Waters STEM Ambassador Program
Waters Education Subscriptions
Meetings & Seminars
BioAccord System Education and Training
eLearning On-Demand Courses
European Training Center Course Listing
The aim of this course is to study the fragmentation of positively and negatively charged even-electron ions of small molecules during in-source CID or MS/MS in triple quadrupole, ion trap, and quadrupole time-of-flight hybrid systems. The emphasis is on spectrum interpretation rather than on fragmentation mechanisms. In addition to lectures and ample time for questions and discussion, the course provides exercises in order to practice spectral interpretation.
Information from mass spectra: Average and monoisotopic mass, mass defects, double-bond equivalents, the nitrogen rule, isotope peaks, adduct ions and adduct-bound dimersFragmentation techniques: Collision-induced dissociation (CID), In-source CID, Triple quadrupole, ion trap and quadrupole-time-of-flight (QTof) hybrid instruments. General aspects of fragmentation: Basic fragmentation mechanisms as well as the ability to discuss fragmentation as charge-site-directed process are investigated.Fragmentation of even-electron positive ions 1: Oxygen compounds -1: Alcohols, ethers, glycosides, aldehydes, ketones, flavonoids, and steroids. Fragmentation of even-electron positive ions 2: Oxygen and sulphur compounds -2: Carboxylic acids, esters, triacylglycerols, as well as various sulfur compounds, e.g., sulfonamide antibiotics. Fragmentation of even-electron positive ions 3: Nitrogen compounds -1: Amines, cyclic amines, quaternary ammonium compounds, and aromatic nitrogen compounds like triazines. Fragmentation of even-electron positive ions 4: Nitrogen compounds -2: Amides, carbamates, organophosphorous compounds, halogenides, nitro-compounds, nitrosamines, and some aromatic heterocyclic ring compounds. Strategies for confirmation and identification using LC/MS/MS.
Anyone that wants to learn how to interpret mass spectra
At least 6 months experience with LC/MS
Each attendee will receive a course manual to keep for future reference and a Certificate of Attendance.
Customer cancellations will carry a surcharge. Courses are run with small numbers
for maximum effect. Cancellation/transfers within 3-4 weeks of the course start
date will incur a charge of 20% of the course fee, 2-3 weeks prior, 50% of
the course fee, 1 week prior, 100% of course fee.
Waters Corporation reserves the right to cancel any course 10 business days
prior to the course's start date, when minimum enrolment is not met.
For travel information for our Wilmslow facility, click here.
610 Centennial Park
The Waters UK headquarters is located adjacent to M1 junction 4, and is within easy reach of central London and is served by two airports, London Heathrow (28 miles) and London Luton (21 miles).
The Corporate Centre for MS Technology Research, Development and Manufacturing
Waters Wilmslow is situated minutes away from the most accessible international airport in the UK, gateway to 180 destinations worldwide. Manchester Airport also has regular shuttle feeder flights to London and EU gateways