• Application Note

Ketoconazole

Ketoconazole
  • Waters Corporation
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This is an Application Brief and does not contain a detailed Experimental section.

Abstract

This application brief demonstrates the analysis of Ketoconazole using Symmetry Columns.  

Introduction

The compounds analyzed in this study are:

  1. Ketoconazole 
  2. Terconazole 

Experimental

HPLC Method

Column:

Symmetry Shield RP18, 4.6 x 250 mm, 5 µm

Part number:

186000112

Mobile phase:

70% diisopropylamine solution/30% ammonium acetate solution

Diisopropylamine solution: 2 mL diisopropylamine in 1 L methanol

Ammonium acetate solution: 1 g in 200 mL of water

Flow rate:

1.5 mL/min

Injection volume:

20 µL

Detection:

UV @ 225 nm

USP Tailing Factors

  1. 1.03 
  2. 1.06 

Results and Discussion

Featured Products

WA31763.94, June 2003

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