IonHance MS-Grade Mobile Phase Additives and Buffers

IonHance MS-Grade Mobile Phase Additives and Buffers

Maximize data quality with high-purity modifiers and buffers 

Maximize data quality with high-purity modifiers and buffers 

Improving analyte retentivity and peak shape in liquid chromatography (LC) is critical, and mobile-phase additives (i.e., strong acids or buffers) are a common way to do just that. MS applications specifically require high purity mobile-phase additives to reduce background contribution and ensure data quality.

IonHance modifiers can be used for LC and LC-MS techniques, such as reversed-phase separations of proteins, peptides, and small molecules. Purified to achieve low metal content and high-quality standards, IonHance modifiers can improve the sensitivity, retentivity, and peak shape of even the toughest separations. The IonHance pH buffer concentrates provide on-line LC-MS analysis for charge variant analysis.

IonHance Difluoriacetic Acid (DFA). The first available MS-grade DFA. IonHance MS-Grade Mobile Phase Additives and Buffers

Specifications

Overview

  • Improved MS Signal over TFA
  • Improved optical peak shape and retention over FA
  • MS-grade offers high purity and low salt
  • IonHance CX-MS pH concentrates simplify LC-MS analysis of mAb charge variants

Recommended Use: Text here.


IonHance MS-Grade Mobile Phase Additives Characteristics

IonHance MS-Grade Mobile Phase Additives Characteristics

IonHance Difluoroacetic Acid
  • First available MS-grade DFA that offers high purity and low salt adducts
  • Improved MS signal over TFA

IonHance Concentrates and Buffers Characteristics

IonHance Concentrates and Buffers Characteristics
IonHance CX-MS pH Concentrate
  • Designed to deliver robust charge-based separations and high quality, on-line MS-spectral data
  • Provide reproducible charge variant LC-MS analyses of Intact mAb and mAb IdeS digests
IonHance Glycan C18 AX Ammonium Formate Concentrate
  • Provides robust, high resolution charge profiling of released glycans
  • Designed to perform a dual mode (salt and organic) gradient method to support mixed-mode chromatography
Ammonium Acetate pH 6.8 Concentrate
  • Designed to support LC and LC-MS techniques utilizing ammonium acetate mobile phases

Better MS signal, optical peak shape and retention

IonHance Difluoroacetic Acid is purified through a distillation process to improve the quality of the modifiers. After purification, samples are QC tested to ensure metal content <100 ppb by ICP-MS and purity ≥98% by GC. IonHance DFA is the first available MS-grade DFA that offers high purity and low salt adducts. With IonHance, your lab can achieve an improved MS signal over TFA and improved optical peak shape and retention over FA.


Simplify the on-line LC-MS analysis of mAb charge variants

IonHance CX-MS pH Concentrates and mobile-phase buffers were designed to deliver robust charge-based separations and high-quality, on-line MS-spectral data when used with the BioResolve SCX mAb Columns. IonHance CX-MS pH Concentrates and mobile-phase buffers are specifically formulated to provide reproducible charge variant LC-MS analyses of Intact mAb and mAb IdeS digests. These concentrates deliver cleaner spectra and significantly reduce non-desired noise, super charging, and ion suppression.




Resources

Documents

Documents


Support

Support


Related

Streamline analytical challenges associated with mAb characterizations and associated biotherapeutic drug separations with Waters BioResolve Columns and consumables.

Achieve increases in sensitivity and analyte recovery while reducing column passivation time and mitigating unwanted analyte/surface interactions with ACQUITY Premier Columns.

Enhance and validate protein applications performed on UPLC, HPLC, or LC-MS instrumentation. Waters Protein Standards and Protein Mixes are specially formulated and designed to aid in the evaluation and benchmarking of columns designed and used for protein separations.

Offers and Discounts

Back To Top Back To Top