BioAccord LC-MS System
Simplicity in every analysis. Power in every insight
The BioAccord LC-MS System is designed for definition and monitoring of biotherapeutic attributes across biopharmaceutical process and product development, manufacturing, and QC. It accomplishes these tasks within a small benchtop footprint on a platform capable of operation by non-MS experts. Analyze a broad range of protein product attributes at the intact, subunit, peptide map, and released glycan levels. Analyze oligonucleotide and nucleic acid products using intact mass confirmation, MS1 digested fragment mapping, and deeper MS2 based sequence confirmation. Assess bioprocess effectiveness and robustness by studying cell culture media and product attributes.
- Make rapid, confident decisions with accessible, consistent high-quality data.
- Analyze complex biomolecules with greater selectivity, specificity, and dynamic range than optical detection based chromatographic and electrophoretic methods.
- Ensure operational simplicity, result consistency, and lab productivity with full workflow automation.
- Deploy compliance-ready waters_connect network-scalable informatics, supporting a combination of HRMS (QTof and BioAccord) and optical-only detection systems from early product characterization to final product release.
BioAccord LC-MS System
Overview
- Make more informed, data-driven decisions with LC-MS data available at the point of decision-making.
- Focus your team on more complex challenges with a system that doesn't require LC-MS experts for routine operation.
- Complement the complicated MS systems you use for product characterization with a platform optimized for streamlined attribute analysis.
- Diagnose and fix potential system issues before they affect data quality with intelligent system monitoring.
- Get a compliant-ready platform ideal to deploy from discovery to quality control.
Recommended Use: For the rapid and multiplexed measurement of product quality attributes across discovery, development, manufacture, and release of biotherapeutics.
Features Header
Accelerate decisions with less effort to collect and process high quality data
Minimize the time spent generating data and managing LC-MS performance and maximize time for actions driven by the high quality data generated with automated set-up and guided workflows. Use the streamlined workflows with the BioAccord LC-MS System for:
- Intact mass analysis (proteins, subunits, oligonucleotides, mRNA fragments)
- Peptide mapping and multi-attribute method (MAM)
- Released N-glycan analysis
- Oligonucleotide sequence confirmation
- Impurity analysis for proteins, peptides, and oligonucleotides
These workflows streamline method set-up, data acquisition and processing, and report generation to deliver the required information with minimal manual interventions. In addition to these core workflows, the BioAccord System also supports a range of other applications required in biotherapeutic process and product development, like cell culture media analysis, mRNA cap, and lipid nanoparticle analysis.
Increase data quality and productivity and reduce analysis failures
Non-specific adsorption of metal sensitive compounds is unpredictable and challenging, leading to long system passivation times, large relative standard deviations (RSDs), and broad peaks that can be tough to detect.
BioAccord LC-MS System incorporates ACQUITY Premier UPLC and Premier chemistries with MaxPeak High Performance Surfaces (HPS) Technology to raise system readiness, decrease time to operation, and improve consistency and sensitivity for the separation and detection of metal interacting analytes. Through the application of MaxPeak HPS Technology, you can:
- Increase recovery and consistent detection of problematic peptides for enhanced peptide map and MAM analysis.
- Achieve superior sensitivity and reproducibility for acidic glycans and lipids by minimizing analyte/surface interactions that lead to sample loss.
- Save time and improve productivity by reducing or eliminating passivation for robust oligonucleotide analyses.
- Minimize the risk of undetected peaks by minimizing metal-sensitive analyte loss, improving recovery and the lowering limits of detection.
Obtain quality data, faster than ever before
Quickly getting the quality data you need for your laboratory to stay productive is paramount but deploying traditional LC-MS systems is often rather slow. The integrated nature of the BioAccord LC-MS System means the system can be deployed easily and users can be productive faster through the delivery of system and applications training with appropriate biopharmaceutical methods, sample data, and system check standards for the common biopharmaceutical analysis workflows.
With the BioAccord LC-MS System, you can:
- Ensure optimal system performance with application-specific installation testing.
- Enable users to quickly get up to speed with outcome-based application training.
- Achieve high quality data with existing personnel or respond quickly to staff and project turnover challenges with reduced training burdens.
Meeting your regulatory requirements, together
Meeting corporate and regulatory expectations for compliance and data integrity is critical to your laboratory operations, and those needs don’t change because LC-MS technology is moving into roles within manufacturing and quality control (QC) organizations.
Your data quality and compliance are our priority, too. The BioAccord System is built on the compliant-ready waters_connect informatics platform and backed by the long history at Waters of delivering compliant informatics and professional qualification services to streamline deployment.
With Waters, you’ll get:
- A single informatics platform based on a secure relational database architecture
- Full audit trail for acquisition, processing, and reporting of data
- Administrator-configurable roles and permissions
- Network deployment of systems for maximum data safety and controlled accessibility
- Characterization (Q-Tof) and routine analysis (BioAccord) systems on a common network for efficient system, data, and information management
- Professional qualification services
Features Header
Accelerate decisions with less effort to collect and process high quality data
Minimize the time spent generating data and managing LC-MS performance and maximize time for actions driven by the high quality data generated with automated set-up and guided workflows. Use the streamlined workflows with the BioAccord LC-MS System for:
- Intact mass analysis (proteins, subunits, oligonucleotides, mRNA fragments)
- Peptide mapping and multi-attribute method (MAM)
- Released N-glycan analysis
- Oligonucleotide sequence confirmation
- Impurity analysis for proteins, peptides, and oligonucleotides
These workflows streamline method set-up, data acquisition and processing, and report generation to deliver the required information with minimal manual interventions. In addition to these core workflows, the BioAccord System also supports a range of other applications required in biotherapeutic process and product development, like cell culture media analysis, mRNA cap, and lipid nanoparticle analysis.
Increase data quality and productivity and reduce analysis failures
Non-specific adsorption of metal sensitive compounds is unpredictable and challenging, leading to long system passivation times, large relative standard deviations (RSDs), and broad peaks that can be tough to detect.
BioAccord LC-MS System incorporates ACQUITY Premier UPLC and Premier chemistries with MaxPeak High Performance Surfaces (HPS) Technology to raise system readiness, decrease time to operation, and improve consistency and sensitivity for the separation and detection of metal interacting analytes. Through the application of MaxPeak HPS Technology, you can:
- Increase recovery and consistent detection of problematic peptides for enhanced peptide map and MAM analysis.
- Achieve superior sensitivity and reproducibility for acidic glycans and lipids by minimizing analyte/surface interactions that lead to sample loss.
- Save time and improve productivity by reducing or eliminating passivation for robust oligonucleotide analyses.
- Minimize the risk of undetected peaks by minimizing metal-sensitive analyte loss, improving recovery and the lowering limits of detection.
Obtain quality data, faster than ever before
Quickly getting the quality data you need for your laboratory to stay productive is paramount but deploying traditional LC-MS systems is often rather slow. The integrated nature of the BioAccord LC-MS System means the system can be deployed easily and users can be productive faster through the delivery of system and applications training with appropriate biopharmaceutical methods, sample data, and system check standards for the common biopharmaceutical analysis workflows.
With the BioAccord LC-MS System, you can:
- Ensure optimal system performance with application-specific installation testing.
- Enable users to quickly get up to speed with outcome-based application training.
- Achieve high quality data with existing personnel or respond quickly to staff and project turnover challenges with reduced training burdens.
Meeting your regulatory requirements, together
Meeting corporate and regulatory expectations for compliance and data integrity is critical to your laboratory operations, and those needs don’t change because LC-MS technology is moving into roles within manufacturing and quality control (QC) organizations.
Your data quality and compliance are our priority, too. The BioAccord System is built on the compliant-ready waters_connect informatics platform and backed by the long history at Waters of delivering compliant informatics and professional qualification services to streamline deployment.
With Waters, you’ll get:
- A single informatics platform based on a secure relational database architecture
- Full audit trail for acquisition, processing, and reporting of data
- Administrator-configurable roles and permissions
- Network deployment of systems for maximum data safety and controlled accessibility
- Characterization (Q-Tof) and routine analysis (BioAccord) systems on a common network for efficient system, data, and information management
- Professional qualification services
Features Header
Accelerate decisions with less effort to collect and process high quality data
Minimize the time spent generating data and managing LC-MS performance and maximize time for actions driven by the high quality data generated with automated set-up and guided workflows. Use the streamlined workflows with the BioAccord LC-MS System for:
- Intact mass analysis (proteins, subunits, oligonucleotides, mRNA fragments)
- Peptide mapping and multi-attribute method (MAM)
- Released N-glycan analysis
- Oligonucleotide sequence confirmation
- Impurity analysis for proteins, peptides, and oligonucleotides
These workflows streamline method set-up, data acquisition and processing, and report generation to deliver the required information with minimal manual interventions. In addition to these core workflows, the BioAccord System also supports a range of other applications required in biotherapeutic process and product development, like cell culture media analysis, mRNA cap, and lipid nanoparticle analysis.
Increase data quality and productivity and reduce analysis failures
Non-specific adsorption of metal sensitive compounds is unpredictable and challenging, leading to long system passivation times, large relative standard deviations (RSDs), and broad peaks that can be tough to detect.
BioAccord LC-MS System incorporates ACQUITY Premier UPLC and Premier chemistries with MaxPeak High Performance Surfaces (HPS) Technology to raise system readiness, decrease time to operation, and improve consistency and sensitivity for the separation and detection of metal interacting analytes. Through the application of MaxPeak HPS Technology, you can:
- Increase recovery and consistent detection of problematic peptides for enhanced peptide map and MAM analysis.
- Achieve superior sensitivity and reproducibility for acidic glycans and lipids by minimizing analyte/surface interactions that lead to sample loss.
- Save time and improve productivity by reducing or eliminating passivation for robust oligonucleotide analyses.
- Minimize the risk of undetected peaks by minimizing metal-sensitive analyte loss, improving recovery and the lowering limits of detection.
Obtain quality data, faster than ever before
Quickly getting the quality data you need for your laboratory to stay productive is paramount but deploying traditional LC-MS systems is often rather slow. The integrated nature of the BioAccord LC-MS System means the system can be deployed easily and users can be productive faster through the delivery of system and applications training with appropriate biopharmaceutical methods, sample data, and system check standards for the common biopharmaceutical analysis workflows.
With the BioAccord LC-MS System, you can:
- Ensure optimal system performance with application-specific installation testing.
- Enable users to quickly get up to speed with outcome-based application training.
- Achieve high quality data with existing personnel or respond quickly to staff and project turnover challenges with reduced training burdens.
Meeting your regulatory requirements, together
Meeting corporate and regulatory expectations for compliance and data integrity is critical to your laboratory operations, and those needs don’t change because LC-MS technology is moving into roles within manufacturing and quality control (QC) organizations.
Your data quality and compliance are our priority, too. The BioAccord System is built on the compliant-ready waters_connect informatics platform and backed by the long history at Waters of delivering compliant informatics and professional qualification services to streamline deployment.
With Waters, you’ll get:
- A single informatics platform based on a secure relational database architecture
- Full audit trail for acquisition, processing, and reporting of data
- Administrator-configurable roles and permissions
- Network deployment of systems for maximum data safety and controlled accessibility
- Characterization (Q-Tof) and routine analysis (BioAccord) systems on a common network for efficient system, data, and information management
- Professional qualification services
Features Header
Accelerate decisions with less focus on collecting and processing data
Minimize the time spent generating data and managing LC-MS performance with automated set-up and guided workflows to maximize time for acting upon those results. Use the streamlined workflows with the BioAccord LC-MS System for:
- Intact mass analysis (proteins, subunits, oligonucleotides, mRNA fragments)
- Noncovalent analysis of aggregates and complexes, SEC-MS, and IEX-MS
- Peptide mapping and multi-attribute method (MAM)
- Released N-glycan analysis
- Oligonucleotide mass and sequence confirmation
- Nucleic acid digested fragment mapping and fragmentation-based sequencing.
- Impurity analysis for proteins, peptides, and oligonucleotides
- Profiling of cell culture media
These automated workflows streamline method set-up, data acquisition, processing, and report generation to deliver the required information with minimal user interventions. In addition to these core workflows, the BioAccord System also supports a range of other applications required in biotherapeutic process and product development, like cell culture media analysis, mRNA capping efficiency, and lipid nanoparticle analysis.
Drive productivity gains by increasing data quality and reducing analysis failures
Non-specific adsorption of metal sensitive analytes can be unpredictable and challenging, leading to long system passivation times, large relative standard deviations (RSDs), and broad peaks that can be tough to detect and quantify.
The BioAccord LC-MS System incorporates ACQUITY Premier UPLC and Premier chemistries with MaxPeak High Performance Surfaces (HPS) Technology. These innovations maximize system readiness, decrease time to operation, and enable superior run-run and system-system consistency while improving sensitivity for the metal interacting analytes. Through the application of MaxPeak HPS Technology, you can:
- Increase recovery and consistent detection of problematic peptides for enhanced peptide map and MAM analysis.
- Achieve superior sensitivity and reproducibility for acidic glycans and lipids by minimizing analyte/surface interactions that lead to sample loss.
- Save time and improve productivity by reducing or eliminating passivation for robust oligonucleotide analyses.
- Minimize the risk of undetected peaks by minimizing metal-sensitive analyte loss, improving recovery and the lowering limits of detection.
Obtain quality data, faster than ever before
Quickly getting the quality data you need for your laboratory to stay productive is paramount. The BioAccord LC-MS System can be deployed easily and users can quickly become productive with applications training that uses appropriate biopharmaceutical methods, sample data, and system check standards for the common biopharmaceutical analysis workflows.
With the BioAccord LC-MS System, you can:
- Ensure optimal system performance with biomolecule-based installation testing.
- Enable users to quickly get up to speed with outcome-based application training.
- Achieve high quality data with existing personnel or respond quickly to staff and project turnover challenges with reduced training burdens.
Meeting your regulatory requirements, together
Meeting corporate and regulatory expectations for compliance and data integrity is critical to your laboratory operations, and those expectations continue to rise as LC-MS technology moves into manufacturing and quality control (QC) organizations.
The BioAccord System is built on the compliant-ready waters_connect informatics platform and backed by Waters history of delivering compliant informatics and professional qualification services to streamline deployment and operations.
With Waters, you’ll get:
- A single informatics platform based on a secure relational database architecture
- Full audit trail for acquisition, processing, and reporting of data
- Administrator-configurable roles and permissions
- Network deployment of systems for maximum data safety and controlled accessibility
- Characterization (Q-Tof) and attribute-based analysis (BioAccord) systems on a common network with optical detection systems for efficient system, data, and information management
- Professional training and qualification services
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