XTerra Columns

XTerra Columns

Optimal selectivity at any pH for more robust separations

Optimal selectivity at any pH for more robust separations

Historically, limitations of the stationary phase material have imposed restrictions on speed, resolution, pH, temperature, and loading capacity for scientists doing HPLC separations. XTerra HPLC Columns retain the advantages of silica without restrictions on speed, resolution, pH/temperature instability and loading.

XTerra Columns, which use the first generation of Hybrid Particle Technology (HPT), broke these boundaries and enabled scientists like you to realize the full potential of analytical and preparative separations.

Resolve your toughest separation challenges with XTerra Column chemistries, which include C18, C8, and Phenyl chemistries providing a wide range of selectivity.

Specifications

Overview

  • Achieve longer column lifetimes at high pH, pH >8.0
  • Get robust separations for basic compounds at high pH
  • Reduce surface silanols for exceptionally sharp, high-efficiency peaks for basic compounds
  • Obtain analytical performance in preparative dimensions with maximum column stability

Recommended Use: For high pH drug discovery, method development, and purification separations.


XTerra Column Chemistries

XTerra Column Chemistries

XTerra MS Columns
  • MS applications
  • High efficiency
  • Wide pH range
  • Chemically stable
  • Long column lifetime

Designed to be compatible with MS applications and provide sharp peaks, good sensitivity, and large peak capacity.

XTerra RP Columns
  • General purpose
  • High efficiency
  • Wide pH range
  • Chemically stable
  • Long column lifetime

Combines hybrid particle technology with shield technology to deliver superior basic analyte peak shape for successful method development.

XTerra Phenyl Columns
  • High efficiency
  • Wide pH range
  • Different selectivity to C18
  • Long column lifetime

Combines hybrid particle technology with phenyl chemistry to give optimal surface coverage, sharp peaks, and reproducibly retention times. Provides complimentary selectivities especially for compounds with aromatic rings.


Ruggedness, efficiency and speed

The Hybrid Particle Technology of XTerra HPLC Columns overcomes the limitations of silica-based and polymer-based stationary-phases by combining the best attributes of both these materials while overcoming each material’s weaknesses. The result is a rugged material that has high mechanical strength, high efficiency, excellent peak shape for bases, and easy scale-up from analytical to preparative chromatography.


Develop robust separations in less time

One of the greatest challenges facing method development scientists is creating a robust separation in the most time-efficient manner possible. XTerra Columns have a usable pH range (pH 1-12) that is twice as wide as silica-based LC columns, making method development twice as easy and twice as fast.


Direct scale-up capability

Combining the patented Optimum Bed Density (OBD) design with the unique chromatographic properties of Hybrid Particle Technology enables XTerra Prep OBD Chromatography Columns to deliver analytical performance in preparative dimensions with maximum column stability. With these capabilities, new drug candidates can go directly from the lead generation to the lead optimization stage of drug discovery. The ability to operate at high pH provides excellent peak shapes for bases and increased mass loading (upto 60x) as compared to conventional silica-based materials.



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