Symmetry HPLC Columns

Symmetry HPLC Columns

Silica-based columns that exceed HPLC column performance expectations

Silica-based columns that exceed HPLC column performance expectations

Reproducible HPLC columns are essential when developing analytical methods for pharmaceutical and biopharmaceutical products. Achieving the same chromatographic results over the lifetime of a new drug product is critical, and no other silica-based LC column brand can match the column-to-column and batch-to-batch reproducibility of the Symmetry family.

Available in column and guard formats, Symmetry Columns are manufactured using high purity silica and tightly controlled manufacturing processes to ensure that you receive a column that exceeds the standards for HPLC column performance.

Specifications

Overview

  • Deliver maximum reproducibility batch-to-batch and column-to-column
  • Provide superior peak shape
  • Achieve high recoveries of peptides and proteins
  • Manufactured using high purity silica and tightly controlled manufacturing processes

Recommended Use: For rugged and reproducible HPLC column performance.


Symmetry Column Characteristics

Symmetry Column Characteristics

Symmetry C18 and C8
  • General purpose
  • High efficiency
  • Reversed-phase columns

Delivers maximum reproducibility

Symmetry Shield RP18 and RP8
  • General purpose
  • High efficiency
  • Reversed-phase columns

Superior peak shape for basic analytes at neutral pH

Symmetry300 C18 and C4
  • Quality control tested with peptides
  • Wide pore
  • Reversed-phase columns

Provides high recoveries of peptides and proteins


Rugged and reproducible HPLC column performance

With Symmetry HPLC Columns, you’ll achieve reliable column-to-column and batch-to-batch reproducibility. Symmetry’s narrow column specification ranges minimize variation, giving you the confidence that the methods you use today will continue to be used in the future.


Superior peak shape

Symmetry Shield Columns feature the Waters patented embedded polar group technology that shields the silica's residual silanols from highly basic analytes and improves overall peak shape. Placing the embedded polar group close to the silica surface further reduces surface silanol activity, and the embedded polar group technology allows you to improve chromatographic peak shape and selectivity in the most challenging of method conditions.


Deliver high peptide recovery

All Symmetry300 columns are QC tested with peptide samples to ensure exceptional batch-to-batch reproducibility. These wide-pore (300 Å), reversed-phase chromatography columns deliver superior performance when simultaneously separating hydrophilic and hydrophobic peptides, neutral, and highly basic peptides. With a Symmetry300 column, you can expect better performance with either high or low mass loads.



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