• Application Note

Pseudoephedrine HCL and Chlorpheniramine

Pseudoephedrine HCL and Chlorpheniramine
  • Waters Corporation
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This is an Application Brief and does not contain a detailed Experimental section.

Abstract

This application brief highlights the analysis of Pseudoephedrine HCL and Chlorpheniramine using Symmetry columns. 

Introduction

The compounds analyzed in this study are:

  1. Pseudoephedrine HCL 
  2. Chlorpheniramine 
Compounds

Experimental

HPLC Method

Column:

Symmetry C18, 3.9 x 150 mm, 5 μm

Part number:

WAT046970

Mobile phase A:

50 mM potassium phosphate, pH 3.0

Mobile phase B:

Acetonitrile

Flow rate:

1.0 mL/min

Injection volume:

5 μL of 1.8 mg/mL pseudoephedrine and 120 μg/mL chlorpheniramine sample

Detection:

UV @ 261 nm

Gradient Table

Gradient Table

USP Tailing Factors

  1. 1.7
  2. 1.2 

Results and Discussion

Results

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WA31763.137, June 2003

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