• Application Note

Metoprolol Tartrate and Oxprenolol

Metoprolol Tartrate and Oxprenolol
  • Waters Corporation
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This is an Application Brief and does not contain a detailed Experimental section.

Abstract

This application brief demonstrates analysis of Metoprolol Tartrate and Oxprenolol.

Introduction

The compounds analyzed are - Metoprolol Tartrate and Oxprenolol.

USP Tailing Factors

  1. 1.29
  2. 1.98

Experimental

HPLC Method

Column:

Symmetry Shield RP18, 4.6 x 250 mm, 5 μm

Part number:

186000112

Mobile phase:

1.92 g of 1-pentansulfonic acid sodium salt monohydrate, 0.27 g of sodium acetate trihydrate and 1.14 mL glacial acetic acid in 940 mL of water; 54% methanol/46% buffer

Flow rate:

1.0 mL/min

Injection volume:

30 μL

Detection:

UV @ 254 nm

Results and Discussion

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WA31763.101, June 2003

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