Analytical Scale Purification System
Bring your analytical purification performance to the next level
Scaling up from analytical methods to preparative methods can be uniquely challenging. The Analytical Scale Purification System is a fully automated purification solution designed for purification labs that need more efficient purification on smaller prep scales. It offers high-capacity sample processing, fraction collection, and high-pressure capabilities.
With this new solution, your lab can use smaller particle-size preparative columns and directly scale-up peak- and time-based purification to achieve more efficient and better resolution, greater precision, and higher recovery, so you can maximize sample yield and purity. Effortlessly streamline your purification workflow and accelerate drug-to-market while reducing laboratory operating costs with the Analytical Scale Purification System.
Analytical Scale Purification System
Overview
- Achieve easier scale-up from UPLC (sub-2-µm column methods), reducing method development and scale-up time
- Accelerate your chromatography with improved resolution and sensitivity through sub-5-µm particle-size preparative columns
- Reduce organic solvent usage, dry-down time, waste disposal, and operating costs
- Obtain predictable scale-up with a multi-column heating and switching column manager to increase your confidence in recovery
- Accurately detect various small and large molecule compounds through high-performance detection capabilities, including PDA, UV/Vis, evaporative light scattering (ELS), and mass detection
- Offer high-capacity sample processing/fraction collecting in smaller purification scales
- Minimize sample loss and maximize information by utilizing the Isocratic Solvent Manager, which enables triple detection options (UV, ELSD, MS)
- Benefit from an integrated offering of industry-leading chemistry and software solutions
Recommended Use: For high-capacity sample processing and fraction collection in smaller prep scales, and more efficient and cost-effective purification solutions.
Proven performance to maximize sample yield and purity
Achieve faster chromatography with improved resolution and sensitivity on the Analytical Scale Purification System using sub-5-µm particle-size preparative columns, supported by accurate and precise solvent delivery with high-pressure Arc HPLC Quaternary Solvent Managers.
- Flow rate ranges up to 10 mL/min
- High-pressure capabilities up to 9500 psi
Predictable scale-up with multicolumn heating and switching
Achieve the predictable scale-up and confidence in recovery your lab needs with CM-30S Column Manager alongside the Analytical Scale Purification System. The 30-cm, single-zone column manager is designed for multicolumn heating and switching, ensuring consistent temperature control across the columns and directly scaling up analytical method.
- Temperature range: 20 °C–90 °C
- Up to 10 mm ID by 300 mm columns
Access sample injection and collection positions more easily
Easily and automatically manage concurrent sample injection, peak fraction collection, and fraction analysis on a single HPLC or LC-MS platform with Waters 3767 Sample Manager (Injector/Collector) for high-capacity sample processing and fraction collecting in smaller purification scales.
- Fraction capacity: 12 x 96 microtiter plates, 448 test tubes, 576 vials
- Injection volume: 20 µL to 25 mL
- Injection-to-injection cycle times of less than 60 seconds
Accurate small and large molecule compound detection
Achieve accurate detection of small and large molecule compounds (e.g., peptides, oligos, and lipids) through a wide range of high-performance detection capabilities, including photodiode array (PDA), UV/Vis, evaporative light scattering (ELS), and mass detection. Our compact, benchtop single quadrupole ACQUITY QDa II Mass Detector is ideal for accurate mass-directed purification, and offers a mass range of up to 1500 m/z.
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