Oasis PRiME HLB for Bioanalysis

Oasis PRiME HLB for Bioanalysis

Rapid 2- and 3-step SPE for faster and reliable bioanalysis with precision

Rapid 2- and 3-step SPE for faster and reliable bioanalysis with precision
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Are you facing increasing pressure for faster, more reliable bioanalysis?

As the demand for next-generation therapies and generic pharmaceuticals grows, bioanalytical workflows must evolve to keep pace.

Inconsistent sample preparation can lead to matrix effects, workflow variability, and lost productivity. Waters Oasis PRiME HLB streamlines SPE with simple 3-step and 2-step protocols —eliminating conditioning and equilibration for faster, more reliable results while preserving sensitivity and accuracy. Remove 95% of phospholipids from biomatrices to minimize matrix interferences and enhance accuracy. Less effort, more precision—get results faster with Oasis PRiME HLB.

With Oasis PRiME HLB, you benefit from: 

  • Faster, more reproducible SPE for LC-MS workflows
  • Reduced matrix effects for improved sensitivity & accuracy
  • Simple protocols that reduce errors & increase reproducibility
  • High analyte recoveries across acids, bases, and neutral molecules with robust performance
  • Higher lab efficiency with increased throughput
  • Secured product supply to support entire timeline of DMPK studies
  • Enhanced method flexibility for diverse bioanalytical applications
Oasis PRiME HLB

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Create your solid-phase extraction (SPE) protocol in seconds with the Bioanalytical SPE Protocol Genius.

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Oasis PRiME HLB Cartridges

Oasis PRiME HLB Cartridges
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  • Available in multiple cartridge sizes ranging from 1cc/30 mg to 6 cc/500 mg
  • Versatile format sizes allow for a wide range of sample volumes
  • Compatible with both vacuum and positive pressure manifolds
  • Oasis Plus Short and Light Cartridges connect directly to a syringe; no other equipment is required
  • Meets latest ANSI luer standard 80369

Oasis PRiME HLB 96-well Plate

Oasis PRiME HLB 96-well Plate
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  • Available with 10 mg and 30 mg of sorbent per well
  • Flexible sorbent amounts allow for scalability and use for range of sample volumes
  • Compatible with most liquid handling robotic systems for automated, reliable, high-throughput SPE
  • Compatible with both vacuum and positive pressure manifolds

Oasis PRiME HLB 96-well µElution Plate

Oasis PRiME HLB 96-well µElution Plate
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  • Ideal for SPE clean-up and analyte enrichment of low sample volumes of 10 µL – 375 µL
  • Waters unique μElution plate design minimizes analyte loss by reducing sticking and eliminating resolubilizing after dry down
  • Fast SPE extraction (<30 minutes)
  • No evaporation and reconstitution necessary due to elution volume as low as 25 µL
  • Up to a 15x increase in concentration
  • Compatible with most liquid handling robotic systems for automated, reliable high throughput SPE
  • Compatible with both vacuum and positive pressure manifolds

Sample preparation is always advancing at Waters

Simplify sample preparation with Waters Sample Preparation Solutions for Bioanalysis. Waters Oasis SPE Products come in a broad range of sorbents and an array of formats. With Oasis Products, you can meet a wide variety of sample preparation needs, from simple and fast sample matrix clean-up to more complex sample preparation challenges.

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Read more about Oasis Prime HLB

Read more about Oasis Prime HLB
Oasis Prime HLB — The Fastest way to Clean Samples
Oasis PRiME HLB Solid Phase Extraction for High Bioanalytical Plasma Analyte Recovery and Low Matrix Effects of Top-Selling Pharmaceuticals

Scientific Publications

Scientific Publications

Innovative Solid-Phase Extraction Strategies for Improving the Advanced Chromatographic Determination of Drugs in Challenging Biological Samples 

Mahdavijalal, M.; Petio, C.; Staffilano, G.; Mandrioli, R.; Protti, M. Innovative Solid-Phase Extraction Strategies for Improving the Advanced Chromatographic Determination of Drugs in Challenging Biological Samples. Molecules 2024, 29(10), 2278. DOI: 10.3390/molecules29102278.

Quantitative analysis of Sorafenib and Nilotinib in human plasma by SPE-LC-MS

Popescu, M. D. E., Manda, C. V., CALUCICĂ, D., GĂMAN, A., NEAMȚU, J., BIȚĂ, A., ... & Croitoru, O. (2023). QUANTITATIVE ANALYSIS OF SORAFENIB AND NILOTINIB IN HUMAN PLASMA BY SPE-LC-MS. Farmacia, 71(5).

Development and validation of an UPLC-ESI–MS/MS method for simultaneous quantification of antineoplastic agents and their metabolites in human plasma after unintentional exposure

Verscheure, E., Struys, I., Creta, M. et al. Development and validation of an UPLC-ESI–MS/MS method for simultaneous quantification of antineoplastic agents and their metabolites in human plasma after unintentional exposure. Arch Toxicol 99, 259–270 (2025).

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