The Waters GTxResolve 2000 Å SEC column, MaxPeak Premier 3 µm is designed with low-adsorption MaxPeak hardware and advanced bridged ethylene HO-PEO particles. This innovative composition ensures high recovery for GTx drugs ranging from 800 to 2500 Å in diameter, including lipid nanoparticles (LNPs), plasmids, and viral vectors. Engineered for extended column lifetimes, minimal secondary interactions, and enhanced MALS sensitivity, this solution supports the development of multi-attribute platform methods. It enables comprehensive integrity and heterogeneity analyses of LNP formulations, plasmid topology assessments, and improved detection of ejected transgenes and aggregates in viral vector applications.
Chemistry |
SEC |
Separation Mode |
SEC |
Particle Substrate |
Silica |
pH Range Min |
2.5 pH |
pH Range Max |
8 pH |
Temperature Limits |
60 C |
Maximum Pressure |
2000 psi (140 Bar) |
Endcapped |
No |
Bonding Technology |
SEC |
Silanol Activity |
Low |
Particle Shape |
Spherical |
Particle Size |
3 µm |
Endfitting Type |
Parker-style |
Pore Size |
2000 Å |
Format |
Premier Column |
Surface Area |
19 |
System |
HPLC, UHPLC, UPLC |
Particle Technology |
Silica |
Technique |
SEC |
USP Classification |
L33 |
Inner Diameter |
4.6 mm |
Length |
150 mm |
Carbon Load |
1.2 % |
UNSPSC |
41115709 |
Application |
Gene Therapeutics |
Brand |
GTxResolve |
Product Type |
Columns |
Units per Package |
1 pk |