• Application Note

Salicylic Acid and Related Compounds

Salicylic Acid and Related Compounds
  • Waters Corporation
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This is an Application Brief and does not contain a detailed Experimental section.

Abstract

This application brief demonstrates analysis of salicylic acid and related compounds.

Introduction

The compounds used in this study are – 

Compounds

USP Tailing Factors

Phthalic Acid

1.7

Salicylic Acid

1.1

Benzoic Acid

1.4

Experimental

HPLC Method

Column:

Symmetry C18, 3.9 x 150 mm, 5 μm

Part numbers:

WAT046980

Mobile phase:

50 mM potassium phosphate pH 3.0/acetonitrile 70:30

Temperature:

40 °C

Flow rate:

0.7 mL/min

Injection volume:

6 μL of phthalic acid (0.5 mg/mL), benzoic and salicylic acids (1 mg/mL)

Detection:

UV @ 254 nm

Results and Discussion

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WA31763.146, June 2003

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