• Application Note

Tricyclic Antidepressants - Gradient, pH 7.0, XTerra RP18 

Tricyclic Antidepressants - Gradient, pH 7.0, XTerra RP18 
  • Waters Corporation
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This is an Application Brief and does not contain a detailed Experimental section.

Abstract

This application brief demonstrates the analysis of tricyclic antidepressants using XTerra RP18 Columns. 

Introduction

The compounds analyzed in this study are:  

  1. Nordoxepin  
  2. Desipramine  
  3. Nortriptyline  
  4. Doxepin  
  5. Imipramine  
  6. Amitriptyline  
  7. Trimipramine
Compounds

Experimental

Conditions

Column:

XTerra RP18 4.6 x 100 mm, 3.5 µm

Part number:

186000438

Mobile phase A:

10 mM NH4HCO3, pH 7.0

Mobile phase B:

ACN

Flow rate:

1.5 mL/min

Injection volume:

10 µL

Temperature:

50 °C

Detection:

UV @ 250 nm

Instrument:

Alliance 2695, 2996 PDA

Gradient

Gradient
USP Tailing

Results and Discussion

Results

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WA20738.105, June 2002

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