• Application Note

Naltrexone

Naltrexone
  • Waters Corporation
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This is an Application Brief and does not contain a detailed Experimental section.

Abstract

This application brief demonstrates analysis of naltrexone using Symmetry Shield RP8 Column.

Introduction

The compounds used in this study was - 

  1. Naloxone (I.S.)
  2. Naltrexone

USP Tailing Factors

1. 1.05

2. 1.04

Experimental

HPLC Method

Column:

Symmetry Shield RP8, 3.9 x 150 mm, 5 μm

Part number:

WAT200655

Mobile phase:

100 mM Ammonium acetate, pH 5.0/acetonitrile 88:12

Flow rate:

1.0 mL/min

Injection volume:

35 μL (500 μL eluate)

Detection:

UV @ 281 nm

Results and Discussion

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WA31763.106, June 2003

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