• Application Note

Diltiazem HCL- Isolation of Impurities, Transfer from Analytical to Prep Columns

Diltiazem HCL- Isolation of Impurities, Transfer from Analytical to Prep Columns
  • Waters Corporation
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This is an Application Brief and does not contain a detailed Experimental section.

Abstract

This application brief demonstrates the analysis of Diltiazem HCL impurities using Symmetry Columns. 

Introduction

The compound analyzed in this study is diltiazem HCL. 

Experimental

HPLC Method

Column:

A. Symmetry C18, 3.9 x 150 mm, 5 µm

B. Symmetry Prep C18, 7.8 x 150 mm, 7 µm

C. Symmetry Prep C18, 19 x 150 mm, 7 µm

Part numbers:

A. WAT046980

B. WAT066288

C. WAT066240

Mobile phase:

Acetonitrile/0.1% TFA in water 30:70

Flow rates:

A. 0.7 mL/min B. 2.8 mL/min C. 16.6 mL/min

Injection volume:

Diltiazem: A. 0.5 mg B. 2.0 mg C. 11.9 mg

Detection:

UV @ 280 nm

Results and Discussion

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WA31763.76, June 2003

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