BioResolve Premier Columns
High-resolution, fast, reproducible results for peptide characterization, drug discovery, drug development, PAT, and bioprocessing applications.
With BioResolve Premier Columns, your lab can achieve faster and more accurate impurity analysis for GLP-1 receptor agonists (GLP-1 RAs) and other large biomolecules, like monoclonal antibodies (mAbs) and multi-specifics (msAbs), with columns designed to deliver up to 2x higher resolution and 3x faster separations for critical quality attributes.
Built with inert MaxPeak Premier Technology to effectively reduce non-specific adsorption, improving reproducibility, sensitivity, and overall quality of results.
BioResolve Premier Columns
Waters BioResolve Protein A Affinity columns, designed to provide greater analytical sensitivity to enable fast, accurate decision-making.
Specifications
Overview
- Quickly analyze large biomolecules including GLP-1 RAs, peptides, proteins, monoclonal antibodies (mAbs), multi-specifics (msAbs), and other advanced antibody therapeutics
- Enable confident analyses with peptide and protein columns QC tested with relevant GLP-1 RA, insulin, peptide, or protein standards.
- Reduce unwanted analyte/surface interactions with inert MaxPeak High Performance Surfaces Technology
Recommended Use: For faster affinity, reversed-phase (RP) and ion exchange (IEX) chromatography where high throughput is desired, including protein and peptide characterization, development, PAT, upstream and downstream bioprocessing, drug discovery and mass spectrometry labs.
BioResolve Premier Column Featured Technologies
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Reduce analyte/surface interactions -
Increase analyte recovery
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Better peak shape
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Increase sensitivity
BioResolve Premier Column Characteristics
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1st choice for GLP-1 RAs and large peptide RPLC and RPLC-MS
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230Å pore size produces up to 2x higher resolution of critical impurities
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Superficially porous particle provides kinetic advantages
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Optimal peak capacity and peak shape in FA for impurity analysis
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QC batch tested with GLP-1 and insulin standards to ensure column performance consistency
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Enhanced peak shape for easier analysis
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Greater sensitivity for mAbs, multi-specifics, and conjugates
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Faster decision-making and better process control
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Reliable reproducibility injection-to-injection and batch-to-batch
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Simplified 2D applications (e.g., ProA-SEC) on all LC systems including UPLC
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High-pressure tolerance for efficient quality attribute assessment
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Improved peak capacity for better component resolution
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Minimal injection-to-injection carryover for increased confidence of analyses
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Ability to operate at lower temperatures for less on-column sample degradation
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Ensured column-to-column performance by being quality control (QC) tested with a NIST-based, mAb subunit standard
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LC system (HPLC, UHPLC, UPLC) agnostic, doesn’t compromise required separation performance
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Ability to reliably separate, with accurate charge variant quantitation, a wide range of mAbs using optical or LC-MS compatible mobile phases
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Excellent batch-to-batch and column-to-column performance consistency
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LC system (HPLC, UHPLC, UPLC) agnostic, doesn’t compromise required separation performance
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Ensured column-to-column performance by being QC tested with a NIST-based, mAb Charge Variant standard
Confident impurity profiling
Achieve faster and more accurate impurity analysis for GLP-1 RAs and synthetic peptides with BioResolve Peptide Columns with MaxPeak Premier Technology. Designed to deliver up to 2x higher resolution and 3x faster separations, these columns help you see more in every sample while reducing variability across runs and batches.
Faster chromatography for high-throughput applications
BioResolve Premier Columns deliver fast analysis for large biomolecules, including monoclonal antibodies (mAbs), and are ideal for the rapid identification of clones and faster analysis for real-time insights of mAb critical quality attributes. Available in reversed phase (RP) and strong cation exchange (SCX) chemistries for high throughput applications, your lab can achieve fast chromatography with excellent performance.
See and do more by reducing analyte/surface interactions
MaxPeak Premier High Performance Surfaces (HPS) Technology takes the sensitivity of BioResolve Premier Columns to the next level. See and do more by reducing analyte/surface interactions for more reproducible results. With MaxPeak Premier HPS, you increase analyte recovery and obtain a better peak shape for greater confidence in your results.
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