This is an Application Brief and does not contain a detailed Experimental section.
This application brief demonstrates analysis of captopril.
The compound analyzed in this study is captopril.
| 
                     Compounds  | 
                     USP Tailing Factors  | 
            
|---|---|
| 
                     Captopril  | 
                     1.0  | 
            
| 
                     Captopril Disulfide  | 
                     1.2  | 
            
            
        | 
                     Column:  | 
                     Symmetry C18, 3.9 x 150 mm, 5 μm  | 
            
| 
                     Part number:  | 
                     WAT046980  | 
            
| 
                     Mobile phase:  | 
                     0.1% phosphoric acid in water/methanol 60:40  | 
            
| 
                     Flow rate:  | 
                     1.0 mL/min  | 
            
| 
                     Injection volume:  | 
                     10 μL of 200 μg/mL captopril and 20 μg/mL of captopril disulfide  | 
            
| 
                     Temperature:  | 
                     40 °C  | 
            
| 
                     Detection:  | 
                     UV @ 220 nm  | 
            
            
        WA31763.46, June 2003