This is an Application Brief and does not contain a detailed Experimental section.
This application brief highlights the analysis of Terfenadine using SymmetryShield Columns.
Terfenadine structure is shown below.
            
        | 
                     Column:  | 
                     SymmetryShield RP18, 4.6 x 150 mm, 5 μm (p/n:186000109)  | 
            
| 
                     Mobile phase:  | 
                     20 mM phosphate buffer, pH 7.0/acetonitrile 25:75  | 
            
| 
                     Flow rate:  | 
                     1.0 mL/min  | 
            
| 
                     Injection volume:  | 
                     5 μL  | 
            
| 
                     Detection:  | 
                     UV @ 220 nm  | 
            
1. 1.04
            
        WA31763.164, June 2003