• Application Note

Ranitidine in Rat Plasma (H2 Blocker)

Ranitidine in Rat Plasma (H2 Blocker)
  • Waters Corporation
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Ranitidine peptic ulcer disease drug, molecule structure

This is an Application Brief and does not contain a detailed Experimental section.

Abstract

This application brief demonstrates analysis of ranitidine in rat plasma.

Introduction

The compound analyzed in this study is ranitidine.

Experimental

HPLC Method

Column:

Xterra MS C18 2.1 x 30 mm, 3.5 μm

Part number:

186000398

Mobile phase A:

100 mM NH4COOH

Mobile phase B:

ACN

Isocratic mobile phase composition:

30% A; 70% B

Flow rate:

0.2 mL/min

Injection volume:

15 μL

Detection:

MS ESI+

Instrument:

Alliance 2790, Micromas Quattro Ultima

Ion source:

ESI+

Source temperature:

150 °C

Gas cell:

1.5e-3 mbar, 20eV

Desolvation temperature:

350 °C

Cone gas flow:

150 L/hr

Drying gas flow:

600 L/hr

Cone voltage:

20V

Results and Discussion

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WA31764.137, June 2003

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