• Application Note

Prochlorperazine - Isolation of Degradation Products, Transfer from Analytical to Prep

Prochlorperazine - Isolation of Degradation Products, Transfer from Analytical to Prep
  • Waters Corporation
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Abstract

This application brief highlights the analysis of Prochlorperazine using Symmetry and SymmetryPrep columns.

Introduction

This application brief highlights the isolation of degradation products of Prochlorperazine and transfer from analytical to preparatory scale.

Experimental

HPLC Method

Column:

Symmetry C18, 3.9 x 150 mm, 5 μm (p/n: WAT046980)

SymmetryPrep C18, 7.8 x 150 mm, 7 μm (p/n: WAT066288)

Mobile phase A:

0.1% TFA in water

Mobile phase B:

Acetonitrile

Flow rate:

0.7 mL/min

2.8 mL/min

Injection volume:

Prochlorperazine edisylate

A. 0.8 mg, B. 3.2mg

Detection:

UV @ 280 nm

Gradient

Results and Discussion

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WA31763.130, June 2003

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