• Application Note

Pharmaceutical Compounds High Temperature

Pharmaceutical Compounds High Temperature
  • Waters Corporation
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This is an Application Brief and does not contain a detailed Experimental section.

Abstract

This application brief demonstrates analysis of pharmaceutical compounds at high temperature.

Introduction

The compounds used in this study are – 

  1. Lidocaine
  2. Prednisolone
  3. Naproxen
  4. Amitriptyline
  5. Ibuprofen

Experimental

LC Conditions

Column:

Xterra MS C18, 2.1 x 20 mm IS, 2.5 μm, (p/n: 186001921)

Mobile phase A:

10 mM CH3COOHN4, pH 5.0/ACN (97/3)

Mobile phase B:

10 mM CH3COOHN4, pH 5.0/ACN (10/90)

Flow rate:

0.6 mL/min; 1.0 mL/min

Injection volume:

10 μL

Sample concentration:

20 μg/mL

Temperature:

30 °C; 60 °C

Detection:

UV @ 210 nm

Instrument:

Alliance 2795 with 996 PDA

Gradient

Gradient.

Results and Discussion

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WA31787.20, June 2003

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