This is an Application Brief and does not contain a detailed Experimental section.
This application brief highlights the analysis of propranolol in Rat plasma using XTerra C18 columns.
Propranolol in rat plasma has been analyzed in this application brief.
            
        | 
                     Column:  | 
                     XTerra MS C18 2.1 x 30 mm, 3.5 μm (p/n: 186000398)  | 
            
| 
                     Mobile phase A:  | 
                     1.0% NH4OH  | 
            
| 
                     Mobile phase B:  | 
                     ACN  | 
            
| 
                     Isocratic mobile phase composition:  | 
                     50% A; 50% B  | 
            
| 
                     Flow rate:  | 
                     0.2 mL/min  | 
            
| 
                     Injection volume:  | 
                     50 mL  | 
            
| 
                     Detection:  | 
                     MS ESI+  | 
            
| 
                     Instrument:  | 
                     Alliance 2790, Micromass Quattro Ultima  | 
            
| 
                     Ion source:  | 
                     ESI+  | 
            
| 
                     Source temp.:  | 
                     150°C  | 
            
| 
                     Gas cell:  | 
                     1.5e-3 mbar, 25 eV  | 
            
| 
                     Desolvation temp.:  | 
                     350 °C  | 
            
| 
                     Cone gas flow:  | 
                     150 L/hr  | 
            
| 
                     Drying gas flow:  | 
                     600 L/hr  | 
            
| 
                     Cone voltage:  | 
                     20 V  | 
            
            
        
            
        WA20738.092, June 2002