• Application Note

Beta Blockers Scale-Up: TFA

Beta Blockers Scale-Up: TFA
  • Waters Corporation
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Statin and beta-blocker pills and capsules with bottle and stethoscope

This is an Application Brief and does not contain a detailed Experimental section.

Abstract

This application brief highlights the scaling-up of beta-blockers in TFA.

Introduction

Compounds used in this study:

1. Nadolol (100 mg/mL)

2. Metoprolol (100 mg/mL)

3. Propranolol (50 mg/mL)

Experimental

Conditions

Column:

SunFire C18 4.6 x 50 mm, 5 μm (p/n: 186002557)

19 x 50 mm, 5 μm (p/n: 186002566)

Mobile phase A:

0.1% TFA in Water

Mobile phase B:

0.1% TFA in ACN

Temperature:

Ambient

Detection:

UV @ 260 nm

Instrument:

AutoPurification System

Results and Discussion

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WA41886, May 2005

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