• Application Note

Atorvastatin - XTerra MS C18 

Atorvastatin - XTerra MS C18 
  • Waters Corporation
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Atorvastatin cholesterol lowering drug chemical structure

This is an Application Brief and does not contain a detailed Experimental section.

Abstract

This application brief demonstrates the analysis of atrovastatin using XTerra MS C18 Columns. 

Introduction

In this study the compound analyzed is atorvastatin. 

Atorvastatin
Atorvastatin 

Experimental

Conditions

Column:

XTerra MS C18 4.6 x 100 mm, 3.5 µm

Part number:

186000436

Mobile phase A:

10 mM NH4COOH, pH 3.0

Mobile phase A:

10 mM NH4HCO3, pH 7.0

Mobile phase A:

10 mM NH4HCO3, pH 10.0

Mobile phase B:

ACN

Isocratic Conditions as Indicated

Flow rate:

1.4 mL/min

Injection volume:

2 µL

Sample Concentration:

0.25 mg/mL

Temperature:

30 °C

Detection:

UV @ 254 nm

Instrument:

Alliance 2795 HT, 2996 PDA

Mobile Phase pH

USP Tailing

3.0

1.06

7.0

1.23

10.0

1.15

Results and Discussion

Atorvastatin

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WA20738.013, June 2002

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