Fast and Simple Bioanalytical Plasma Sample Extraction Using Oasis® PRiME HLB SPE for High Analyte Recovery
Fast and Simple Bioanalytical Plasma Sample Extraction Using Oasis® PRiME HLB SPE for High Analyte Recovery
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Abstract
This application describes a fast and simple method for bioanalytical sample preparation from plasma. Utilizing Oasis PRiME HLB solid-phase extraction (SPE), the protocol requires no method development and achieves high recovery and low matrix effects for several small molecule pharmaceuticals.
Experimental
Figure 1. Demonstration of Oasis PRiME HLB SPE bioanalytical performance, requiring no optimization of the starting protocol, with high recovery (> 79%) and low matrix effects (-16,2 to 5.4%) for several pharmaceuticals extracted from plasma.
Results and Discussion
High Analyte Recovery with low matrix from plasma is achieved Using Oasis PRiME HLB SPE for top-selling small molecule pharmaceuticals in 2023.1
References
- Williams, RE and Leatherwood HM Top 200 Small Molecule Drugs by Retail Sales in 2023. (accessed 21 June 2024).
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720008423, July 2024
