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Fast and Simple Bioanalytical Plasma Sample Extraction Using Oasis HLB SPE for High Analyte Recovery

Fast and Simple Bioanalytical Plasma Sample Extraction Using Oasis HLB SPE for High Analyte Recovery
  • Kim Van Tran
  • Mary Trudeau
  • Waters Corporation
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Abstract

This application note describes the fast and simple bioanalytical plasma sample extraction using Oasis HLB solid phase extraction, requiring no protocol method development, for high extraction recovery of several small molecule pharmaceuticals.

Experimental

Sample Preparation & Extraction
Sample Preparation & Extraction.

LC-MS Analysis

UPLC Gradient Table

Results and Discussion

High Analyte Recovery from Plasma using Oasis HLB SPE

Demonstration of Oasis HLB SPE Performance requiring no protocol optimization, with >78% recovery and matrix effects <20% from plasma
Figure 1. Demonstration of Oasis HLB SPE Performance requiring no protocol optimization, with >78% recovery and matrix effects <20% from plasma.

Ordering Information

Ordering Information

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720008168, December 2023

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